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1. WO1996004275 - NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Publication Number WO/1996/004275
Publication Date 15.02.1996
International Application No. PCT/FR1995/001033
International Filing Date 01.08.1995
Chapter 2 Demand Filed 12.02.1996
IPC
C07D 405/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 405/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14containing three or more hetero rings
CPC
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 13/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13Drugs for disorders of the urinary system
02of urine or of the urinary tract, e.g. urine acidifiers
A61P 15/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
15Drugs for genital or sexual disorders
A61P 3/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
02Nutrients, e.g. vitamins, minerals
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
A61P 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
Applicants
  • ROUSSEL UCLAF [FR]/[FR] (AllExceptUS)
  • HECKMANN, Bertrand [FR]/[FR] (UsOnly)
  • VEVERT, Jean-Paul [FR]/[FR] (UsOnly)
  • ZHANG, Jidong [CN]/[FR] (UsOnly)
Inventors
  • HECKMANN, Bertrand
  • VEVERT, Jean-Paul
  • ZHANG, Jidong
Agents
  • VIEILLEFOSSE, Jean-Claude
Priority Data
94/0956502.08.1994FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) NOVEL IMIDAZOLE DERIVATIVES, METHOD FOR PREPARING SAME, NOVEL INTERMEDIATES THUS OBTAINED, MEDICINAL APPLICATIONS OF SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
(FR) NOUVEAUX DERIVES DE L'IMIDAZOLE, LEUR PROCEDE DE PREPARATION, LES NOUVEAUX INTERMEDIAIRES OBTENUS, LEUR APPLICATION A TITRE DE MEDICAMENTS ET LES COMPOSITIONS PHARMACEUTIQUES LES RENFERMANT
Abstract
(EN)
Novel products of formula (I), wherein R1 is hydrogen, hydroxy, alkoxy, formyl, dioxol, aryl, arylcarbonyl, arylthio, alkylcarbonyl, R2 and R3 are halogen, mercapto, acyl, carboxy, nitro, cyano, amino, carbamoyl, R4, -OR4, and R4 are hydrogen, alkyl, alkenyl, alkynyl, acyl, amino, -(CH2)m1-S(O)m2-X-R10, wherein m1 = 0-4, m2 = 0-2, X is a single bond or -NH-, -NH-CO-, -NH-CO-NH- and R10 is alkyl, alkenyl or aryl, and Y is optionally substituted aryl, said products being obtained in all the isomeric forms, their salts, and their novel use as medicines.
(FR)
L'invention concerne les produits de formule (I) dans lesquels: R1 représente hydrogène, hydroxy, alcoxy, formyle, dioxol, aryle, arylcarbonyle, arylthio, alkylcarbonyle, R2, R3 représentent notamment halogène, mercapto, acyle, carboxy, nitro, cyano, amino, carbamoyle, R4, -OR4 avec R4 représente notamment hydrogène, alkyle, alkényle, alkynyle, acyle, amino, -(CH2)m1-S(O)m2-X-R10 avec m1 = 0 à 4, m2 = 0 à 2, X représente simple liaison ou -NH-, -NH-CO-, -NH-CO-NH-, et R10 représente alkyle, alkényle ou aryle, et Y représente aryle éventuellement substitué, ces produits étant sous toutes les formes isomères et les sels, leur utilisation à titre de médicaments.
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