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1. WO1996004270 - NOVEL BENZIMIDAZOLE DERIVATIVES

Publication Number WO/1996/004270
Publication Date 15.02.1996
International Application No. PCT/US1995/009895
International Filing Date 04.08.1995
Chapter 2 Demand Filed 01.03.1996
IPC
C07D 403/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
C07D 403/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • SYNAPTIC PHARMACEUTICAL CORPORATION [US/US]; 215 College Road Paramus, NJ 07652, US (AllExceptUS)
  • JEON, Yoon, T. [KR/US]; US (UsOnly)
  • GLUCHOWSKI, Charles [US/US]; US (UsOnly)
Inventors
  • JEON, Yoon, T.; US
  • GLUCHOWSKI, Charles; US
Agents
  • WHITE, John, P.; Cooper & Dunham LLP 1185 Avenue of the Americas New York, NY 10036, US
Priority Data
08/285,95604.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL BENZIMIDAZOLE DERIVATIVES
(FR) NOUVEAUX DERIVES DE BENZIMIDAZOLE
Abstract
(EN)
The invention provides compounds having structure (I), wherein each of R1, R2, R3 and R9 is independently H; straight chain, branched, substituted or unsubstituted alkyl, alkenyl or alkynyl; cycloalkyl, cycloalkenyl; acyl; phenyl; substituted phenyl or heteroaryl; wherein each R4, R5 and R6 is independently H; F; Cl; Br; I; straight chain, branched, substituted or unsubstituted alkyl, alkenyl or alkynyl; cycloalkyl; cycloalkenyl; phenyl; unsubstituted phenyl; heteroaryl; etc. and wherein each R8 is independently H; straight, branched, substituted or unsubstituted alkyl, alkenyl or alkynyl; phenyl or substituted phenyl. These compounds are selective for cloned human alpha 2 receptors and are useful as analgesic, sedative or anaesthetic agents.
(FR)
Cette invention se rapporte à des composés ayant la structure (I) dans laquelle chaque R1, R2, R3 et R9 représente, indépendamment H; alcényle, alkynyle ou alkyle substitué ou non substitué, à chaîne droite ou ramifiée; cycloalkyle; cycloalcényle; acyle; phényle; hétéroaryle ou phényle substitué; chaque R4, R5 et R6 représente, indépendamment, H, F, Cl, Br, I; alcényle, alkynyle ou alkyle substitué ou non substitué, à chaîne droite ou ramifiée; cycloalkyle; cycloalcényle; phényle; phényle non substitué; hétéroaryle; etc. et chaque R8 représente indépendamment H; alcényle, alkynyle ou alkyle substitué ou non substitué, à chaîne droite ou ramifiée; phényle ou phényle substitué. Ces composés sont sélectifs pour les récepteurs alpha 2 humains clonés et sont utilisés comme agents analgésiques, sédatifs ou anesthésiques.
Also published as
Latest bibliographic data on file with the International Bureau