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1. WO1996004268 - 1,4-DIHYDROPYRIDINE COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME

Publication Number WO/1996/004268
Publication Date 15.02.1996
International Application No. PCT/JP1995/001507
International Filing Date 28.07.1995
Chapter 2 Demand Filed 22.11.1995
IPC
C07D 401/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 401/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 417/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14containing three or more hetero rings
CPC
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 417/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
14containing three or more hetero rings
Applicants
  • NIKKEN CHEMICALS CO., LTD. [JP/JP]; 4-14, Tsukiji 5-chome Chuo-ku Tokyo 104, JP (AllExceptUS)
  • TASAKA, Shigeyuki [JP/JP]; JP (UsOnly)
  • MIURA, Teruhisa [JP/JP]; JP (UsOnly)
  • KIUE, Akira [JP/JP]; JP (UsOnly)
  • SEKI, Taketsugu [JP/JP]; JP (UsOnly)
  • SANO, Tetsuro [JP/JP]; JP (UsOnly)
  • KAMAKURA, Mie [JP/JP]; JP (UsOnly)
  • FUJITA, Masakazu [JP/JP]; JP (UsOnly)
Inventors
  • TASAKA, Shigeyuki; JP
  • MIURA, Teruhisa; JP
  • KIUE, Akira; JP
  • SEKI, Taketsugu; JP
  • SANO, Tetsuro; JP
  • KAMAKURA, Mie; JP
  • FUJITA, Masakazu; JP
Agents
  • ISHIDA, Takashi ; A. Aoki & Associates Toranomon 37 Mori Building 5-1, Toranomon 3-chome Minato-ku Tokyo 105, JP
Priority Data
6/19620429.07.1994JP
7/7933113.03.1995JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) 1,4-DIHYDROPYRIDINE COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME
(FR) COMPOSE DE 1,4-DIHYDROPYRIDINE ET COMPOSITION MEDICINALE CONTENANT LEDIT COMPOSE
Abstract
(EN)
A 1,4-dihydropyridine compound represented by general formula (I) or a pharmacologically acceptable salt thereof, and an antiallergic, antiinflammatory, antineoplastic-resistance antagonist, or antineoplastic potentiator, each containing the same as the active ingredient. In said formula, R1 represents -COO-A-(3-pyridyl) and A represents C3-C6 linear alkylene which may have an intervening piperazine ring; R2 represents C2-C10 alkyl, alkenyl or alkynyl, substituted lower alkyl or alkenyl, or optionally substituted cycloalkyl; R3 represents the same group as R1 or -COO-R4; and R4 represents optionally substituted lower alkyl.
(FR)
Composé de 1,4-dihydropyridine de formule générale (I) ou sel pharmaceutiquement acceptable dudit composé, et antagoniste antiallergique, anti-inflammatoire, de résistance antinéoplasique, ou potentialisateur antinéoplasique, contenant tous le même principe actif de formule (I) dans laquelle R1 représente -COO-A-(3-pyridyle) et A représente alkylène linéaire C3-C6 qui peut posséder un cycle pipérazine interposé; R2 représente alcényle, alcynyle ou alkyle C2-C10, alkyle inférieur ou alcényle substitué ou éventuellement cycloalkyle substitué; R3 représente le même groupe que R1 ou -COO-R4; et R4 représente éventuellement alkyle inférieur substitué.
Also published as
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