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1. (WO1996004256) PROCESS FOR PREPARING AN ANTIFUNGAL AZOLE WITH HYDRAZINO AND AMIDRAZONE INTERMEDIATES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/004256    International Application No.:    PCT/GB1995/001815
Publication Date: 15.02.1996 International Filing Date: 01.08.1995
Chapter 2 Demand Filed:    19.02.1996    
IPC:
C07D 521/00 (2006.01)
Applicants: ZENECA LIMITED [GB/GB]; 15 Stanhope Gate, London W1Y 6LN (GB) (AM, AT, AU, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CZ, DE, DK, ES, FI, FR, GA, GB, GE, GN, GR, HU, IE, IT, KE, KG, KP, KZ, LK, LT, LU, LV, MC, MD, MG, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SI, SK, SN, SZ, TD, TG, TJ, TM, TT, UA, UG, UZ, VN only).
DAVIES, Elwyn, Peter [GB/GB]; (GB) (For US Only).
MALLION, Keith, Blakeney [GB/GB]; (GB) (For US Only).
PITTAM, John, David [GB/GB]; (GB) (For US Only).
TAYLOR, Nigel, Philip [GB/GB]; (GB) (For US Only).
MODICHIDA PHARMACEUTICAL CO. LTD. [JP/JP]; 7, Yotsuya 1-chome, Shinjuku-ku, Tokyo 160 (JP) (JP, KR, SG only)
Inventors: DAVIES, Elwyn, Peter; (GB).
MALLION, Keith, Blakeney; (GB).
PITTAM, John, David; (GB).
TAYLOR, Nigel, Philip; (GB)
Agent: DENERLEY, Paul, Millington; Intellectual Property Group, Zeneca Pharmaceuticals, Mereside, Alderley Park, Macclesfield, Cheshire SK10 3TG (GB)
Priority Data:
9415544.7 02.08.1994 GB
Title (EN) PROCESS FOR PREPARING AN ANTIFUNGAL AZOLE WITH HYDRAZINO AND AMIDRAZONE INTERMEDIATES
(FR) PROCEDE DE PREPARATION D'UN AZOLE ANTIFONGIQUE AVEC DES INTERMEDIAIRES HYDRAZINO ET AMIDRAZONE
Abstract: front page image
(EN)A process for preparing an antifungal azole compound of formula (I) by reacting an epoxide with hydrazine to form a hydrazino compound which is subsequently reacted with an iminoether. The amidrazone product is subsequently reacted with an orthoformate to provide the antifungal azole. The azole, known as ZD0870, shows good activity against human fungal infections including Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus.
(FR)Procédé de préparation d'un composé antifongique de type azole représenté par la formule (I), par mise en réaction d'un époxyde avec de l'hydrazine, afin d'obtenir un composé hydrazino mis ensuite en réaction avec un iminoéther. Le produit d'amidrazone est ensuite mis en réaction avec un orthoformate, afin d'obtenir l'azole antifongique. Celui-ci, connu en tant que ZD0870, est efficace contre les infections fongiques chez l'homme, telles que Candida albicans, Cryptococcus neoformans et Aspergillus fumigatus.
Designated States: AM, AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, ES, FI, GB, GE, HU, JP, KE, KG, KP, KR, KZ, LK, LT, LU, LV, MD, MG, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (KE, MW, SD, SZ, UG)
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)