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1. WO1996004246 - PHENYLACETAMIDES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION

Publication Number WO/1996/004246
Publication Date 15.02.1996
International Application No. PCT/EP1995/002958
International Filing Date 26.07.1995
IPC
C07D 215/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
12with substituted hydrocarbon radicals attached to ring carbon atoms
14Radicals substituted by oxygen atoms
C07D 215/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18Halogen atoms or nitro radicals
C07D 401/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
C07D 215/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
12with substituted hydrocarbon radicals attached to ring carbon atoms
14Radicals substituted by oxygen atoms
C07D 215/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
215Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
02having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
16with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18Halogen atoms or nitro radicals
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • LABORATORIOS MENARINI S.A. [ES/ES]; Alfonso XII, 587 E-08912 Badalona, ES (AllExceptUS)
  • MAULEON CASELLAS, David [ES/ES]; ES (UsOnly)
  • CARGANICO, Germano [IT/ES]; ES (UsOnly)
  • GARCIA PEREZ, Maria, Luisa [ES/ES]; ES (UsOnly)
  • FOS TORRO, Mª de los Desamparados [ES/ES]; ES (UsOnly)
Inventors
  • MAULEON CASELLAS, David; ES
  • CARGANICO, Germano; ES
  • GARCIA PEREZ, Maria, Luisa; ES
  • FOS TORRO, Mª de los Desamparados; ES
Agents
  • MINOJA, Fabrizio; Studio Consulenza Brevettuale Via Rossini, 8 I-20122 Milano, IT
Priority Data
P 940169501.08.1994ES
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PHENYLACETAMIDES HAVING LEUKOTRIENE-ANTAGONISTIC ACTION
(FR) PHENYLACETAMIDES PRESENTANT UNE ACTION ANTAGONISTE DES LEUCOTRIENES
Abstract
(EN)
Phenylacetamides of formula (I) wherein the substituent containing a -CONR3- is bound to the 3- or 4- position of the phenol system; the substituent containing B is bound to the benzene ring at any free position; R1 is hydrogen, fluorine, chlorine or -OCH3; R2 is hydrogen, fluorine, chlorine or bromine; R3 is hydrogen or methyl; B is a 5-tetrazolyl group or -COOR4, wherein R4 is hydrogen, a (C1-C4)-alkyl or a phenylalkyl group of less than 10 carbon atoms; m and n are integers from 0 to 6, with the proviso that m + n is less or equal to 6; have leukotriene antagonistic action.
(FR)
On décrit des phénylacétamides de formule (I), où le substituant contenant -CONR3- est lié à la position 3- ou 4- du système phénol; le substituant contenant B est lié au cycle benzène en toute position libre; R1 représente hydrogène, fluor, chlore ou -OCH3; R2 représente hydrogène, fluor, chlore ou brome; R3 représente hydrogène ou méthyle; B représente un groupe 5-tétrazolyle ou -COOR4, où R4 représente hydrogène ou un groupe (C1-4)-alkyle ou phénylalkyle comportant moins de 10 atomes de carbone; m et n représentent des nombres entiers allant de 0 à 6, à condition que m + n soit inférieur ou égal à 6. Ces phénylacétamides présentent une action antagoniste des leucotriènes.
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