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1. WO1996004232 - PROCESS FOR THE PREPARATION OF A SUBSTITUTED 2.5-DIAMINO-3-HYDROXYHEXANE

Publication Number WO/1996/004232
Publication Date 15.02.1996
International Application No. PCT/US1995/009133
International Filing Date 17.07.1995
Chapter 2 Demand Filed 09.02.1996
IPC
C07C 213/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
213Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
C07C 215/32 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
215Compounds containing amino and hydroxy groups bound to the same carbon skeleton
02having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
22the carbon skeleton being unsaturated
28and containing six-membered aromatic rings
30containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
32containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
CPC
C07C 213/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
213Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
C07C 215/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
215Compounds containing amino and hydroxy groups bound to the same carbon skeleton
02having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
22the carbon skeleton being unsaturated
28and containing six-membered aromatic rings
30containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
32containing hydroxy groups and carbon atoms of two six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
Applicants
  • ABBOTT LABORATORIES [US/US]; Chad 0377/AP6D-2 100 Abbott Park Road Abbott Park, IL 60064-3500, US
Inventors
  • HAIGHT, Anthony, R.; US
  • GOODMONSON, Owen, J.; US
  • PAREKH, Shyamal, I.; US
  • ROBBINS, Timothy, A.; US
  • SEIF, Louis, S.; US
Agents
  • CROWLEY, Steven, R. ; Abbott Laboratories Chad 0377/AP6D-2 100 Abbott Park Road Abbott Park, IL 60064-3500, US
Priority Data
08/283,10929.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE PREPARATION OF A SUBSTITUTED 2.5-DIAMINO-3-HYDROXYHEXANE
(FR) PROCEDE DE PREPARATION D'UN 2,5-DIAMINO-3-HYDROXYHEXANE SUBSTITUE
Abstract
(EN)
A process is disclosed for the preparation of the substantially pure compound of formula (I) comprising catalytic hydrogenation of a compound of formula (II) wherein R6 and R7 are independently selected from (i) wherein Ra and Rb are independently selected from hydrogen, loweralkyl and phenyl and Rc, Rd and Re are independently selected from hydrogen, loweralkyl, trifluoromethyl, alkoxy, halo and phenyl; and (ii) wherein the naphthyl ring is unsubstituted or substituted with one, two or three substituents independently selected from loweralkyl, trifluoromethyl, alkoxy and halo; or R6 and R7 taken together with the nitrogen atom to which they are bonded are (a) or (b) wherein Rf, Rg, Rh and Ri are independently selected from hydrogen, loweralkyl, alkoxy, halogen and trifluoromethyl; or an acid addition salt thereof.
(FR)
Procédé de préparation d'un composé pratiquement pur de la formule (I) ou d'un sel d'addition d'acide de celui-ci, comprenant l'hydrogénation catalytique d'un composé de la formule (II) dans laquelle R6 et R7 sont choisis indépendamment entre le groupe (i) où Ra et Rb sont choisis indépendamment entre hydrogène, alkyle inférieur et phényle, et Rc, Rd et Re sont choisis indépendamment entre hydrogène, alkyle inférieur, trifluorométhyle, alcoxy, halo et phényle, et le groupe (ii) où le noyau naphtyle n'est pas substitué ou est substitué par un, deux ou trois substituants choisis indépendamment entre alkyle inférieur, trifluorométhyle, alcoxy et halo; ou bien R6 et R7 pris ensemble avec l'atome d'azote auquel ils sont liés représentent (a) ou (b) dans lesquels Rf, Rg, Rh et Ri sont choisis indépendamment entre hydrogène, alkyle inférieur, alcoxy, halogène et trifluorométhyle.
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