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1. WO1996004230 - TERPENE-QUINONE WITH ANTITUMOR ACTIVITY

Publication Number WO/1996/004230
Publication Date 15.02.1996
International Application No. PCT/ES1995/000096
International Filing Date 01.08.1995
IPC
C07C 45/69 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
45Preparation of compounds having C=O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
61by reactions not involving the formation of C=O groups
67by isomerisation; by change of size of the carbon skeleton
68by increase in the number of carbon atoms
69by addition to carbon-to-carbon double or triple bonds
C07C 46/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
46Preparation of quinones
C07C 49/653 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
49Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
587Unsaturated compounds containing a keto group being part of a ring
647having unsaturation outside the ring
653polycyclic
C07C 50/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
50Quinones
10the quinoid structure being part of a condensed ring system containing two rings
14with unsaturation outside the ring system, e.g. vitamin K1
C07C 50/32 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
50Quinones
26containing groups having oxygen atoms singly bound to carbon atoms
32the quinoid structure being part of a condensed ring system having two rings
C07C 61/35 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
61Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
16Unsaturated compounds
35having unsaturation outside the rings
CPC
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07C 45/69
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
45Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
61by reactions not involving the formation of >C = O groups
67by isomerisation; by change of size of the carbon skeleton
68by increase in the number of carbon atoms
69by addition to carbon-to-carbon double or triple bonds
C07C 46/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
46Preparation of quinones
C07C 49/653
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
49Ketones; Ketenes; Dimeric ketenes
587Unsaturated compounds containing a keto groups being part of a ring
647having unsaturation outside the ring
653polycyclic
C07C 50/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
50Quinones
10the quinoid structure being part of a condensed ring system containing two rings
14with unsaturation outside the ring system, e.g. vitamin K1
C07C 50/32
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
50Quinones
26containing groups having oxygen atoms singly bound to carbon atoms
32the quinoid structure being part of a condensed ring system having two rings
Applicants
  • PHARMA MAR, S.A. [ES]/[ES] (AllExceptUS)
  • GARCIA GRAVALOS, Mª Dolores [ES]/[ES] (UsOnly)
  • GORDALIZA ESCOBAR, Marina [ES]/[ES] (UsOnly)
  • MIGUEL DEL CORRAL SANTANA, Jose Mª [ES]/[ES] (UsOnly)
  • MAHIQUES BUJANDA, Mª del Mar [ES]/[ES] (UsOnly)
  • SAN FELICIANO MARTIN, Arturo [ES]/[ES] (UsOnly)
Inventors
  • GARCIA GRAVALOS, Mª Dolores
  • GORDALIZA ESCOBAR, Marina
  • MIGUEL DEL CORRAL SANTANA, Jose Mª
  • MAHIQUES BUJANDA, Mª del Mar
  • SAN FELICIANO MARTIN, Arturo
Agents
  • URIZAR ANASAGASTI, José Antonio
Priority Data
P 940169701.08.1994ES
P 950081727.04.1995ES
Publication Language Spanish (ES)
Filing Language Spanish (ES)
Designated States
Title
(EN) TERPENE-QUINONE WITH ANTITUMOR ACTIVITY
(ES) TERPENO-QUINONA CON ACTIVIDAD ANTITUMORAL
(FR) TERPENE-QUINONE AVEC ACTIVITE ANTITUMORALE
Abstract
(EN)
Terpene-quinone with antitumor activity defined from a cyclocondensation reaction of Diels-Alder, used to obtain families or series of said compounds having a new structure and presenting a cytotoxic activity to cellular cultures P-388, A-549, HT-29 and MEL-28, with levels of IC50 lower than 1 microgram per unit of millilitre.
(ES)
Terpeno-quinonas con actividad antitumoral, definidas a partir de una reacción de ciclocondensación de Diels-Alder, consiguiéndose familias o series de dichos compuestos de nueva estructura que presentan actividad citotóxica frente a cultivos celulares P-388, A-549, HT-29 y MEL-28, alcanzando niveles de IC50 inferiores a 1 microgramo por unidad de mililitro.
(FR)
Terpène-quinone avec activité antitumorale, définies à partir d'une réaction de cyclocondensation de Diels-Alder, permettant d'obtenir des familles ou séries de composés ayant une nouvelle structure et présentant une activité cytotoxique sur les cultures cellulaires P-388, A-549, HT-29 et MEL-28, atteignant des niveaux de IC50 inférieurs à 1 microgramme par unité de millilitre.
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