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1. WO1996004018 - GAS-FILLED MICROSPHERES WITH FLUORINE-CONTAINING SHELLS

Publication Number WO/1996/004018
Publication Date 15.02.1996
International Application No. PCT/US1995/009618
International Filing Date 31.07.1995
Chapter 2 Demand Filed 12.02.1996
IPC
A61K 49/22 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparations
CPC
A61K 49/223
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
22Echographic preparations; Ultrasound imaging preparation ; Optoacoustic imaging preparations
222characterised by a special physical form, e.g. emulsions, liposomes
223Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
Applicants
  • MOLECULAR BIOSYSTEMS, INC. [US/US]; 10030 Barnes Canyon Road San Diego, CA 92121-2789, US
Inventors
  • LOHRMANN, Rolf; US
Agents
  • PARK, Freddie, K. ; Morrison & Foerster 755 Page Mill Road Palo Alto, CA 94304-1018, US
Priority Data
08/284,78202.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GAS-FILLED MICROSPHERES WITH FLUORINE-CONTAINING SHELLS
(FR) MICROSPHERES DE GAZ A ENVELOPPES A BASE DE FLUOR
Abstract
(EN)
Improved ultrasonic imaging contrast agents are provided which are comprised of an aqueous suspension of microspheres comprising at least one gas, preferably a perfluorocarbon, encapsulated by elastic shells of a biocompatible, fluorine-containing amphiphilic material, processes for making the microspheres, and methods of diagnostic imaging using the improved contrast agents.
(FR)
Agents de contraste pour imagerie par ultrasons faits d'une suspension aqueuse de microsphères comprenant au moins un gaz (de préférence un perfluocarbone) encapsulé dans des enveloppes élastiques biocompatibles d'un produit amphiphilique à base de fluor; procédés d'élaboration desdites microsphères; et méthodes de diagnostic par imagerie recourant auxdits agents.
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