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1. WO1996004010 - VR-2332 VIRAL NUCLEOTIDE SEQUENCE AND METHODS OF USE

Publication Number WO/1996/004010
Publication Date 15.02.1996
International Application No. PCT/US1995/009927
International Filing Date 04.08.1995
Chapter 2 Demand Filed 29.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C12N 2770/10022
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
10011Arteriviridae
10022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Applicants
  • REGENTS OF THE UNIVERSITY OF MINNESOTA [US]/[US]
Inventors
  • MURTAUGH, Michael, P.
  • ELAM, Margaret, R.
  • KAKACH, Laura, T.
Agents
  • COLLINS, John, M.
Priority Data
08/287,94105.08.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) VR-2332 VIRAL NUCLEOTIDE SEQUENCE AND METHODS OF USE
(FR) SEQUENCE NUCLEOTIDIQUE DU VIRUS VR-2332 ET PROCEDES POUR SON UTILISATION
Abstract
(EN)
A nucleotide sequence is provided for the VR-2332 virus, which is capable of causing Porcine Reproductive and Respiratory Syndrome. The nucleotide sequence includes protein coding regions that are inserted into recombinant vectors for the host expression of viral proteins according to a variety of vaccination techniques. Diagnostic assays utilize fragmentary sequences or oligonucleotides to selectively identify the VR-2332 nucleic acids by hybridization or PCR amplification reactions that distinguish VR-2332 nucleotide sequences from other PRRS-causative viruses which are immunologically distinct from VR-2332.
(FR)
L'invention concerne une séquence nucléotidique du virus VR-2332 qui est capable de provoquer le syndrome dysgénique respiratoire porcin. La séquence nucléotidique comprend des régions codant pour des protéines, qui sont insérées dans des vecteurs de recombinaison pour l'expression dans un hôte de protéines virales utilisables dans différentes techniques de vaccination. Pour effectuer des diagnostics, on utilise des segments ou fragments oligonucléotidiques pour identifier sélectivement les acides nucléiques de VR-2332 par hybridation ou par des réactions d'amplification du type PCR qui permettent de distinguer les séquences nucléotidiques de VR-2332 de celles d'autres virus qui peuvent provoquer le syndrome dysgénique respiratoire porcin tout en étant différents de VR-2332 du point de vue immunologique.
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