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1. WO1996003997 - TREATMENT OF CANCER USING HSV MUTANT

Publication Number WO/1996/003997
Publication Date 15.02.1996
International Application No. PCT/GB1995/001791
International Filing Date 28.07.1995
Chapter 2 Demand Filed 27.02.1996
IPC
A61K 35/76 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
C12N 7/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
CPC
A61K 35/763
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
66Microorganisms or materials therefrom
76Viruses; Subviral particles; Bacteriophages
763Herpes virus
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
C12N 2710/16621
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2710dsDNA Viruses
00011dsDNA Viruses
16011Herpesviridae
16611Simplexvirus, e.g. human herpesvirus 1, 2
16621Viruses as such, e.g. new isolates, mutants or their genomic sequences
C12N 2710/16632
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2710dsDNA Viruses
00011dsDNA Viruses
16011Herpesviridae
16611Simplexvirus, e.g. human herpesvirus 1, 2
16632Use of virus as therapeutic agent, other than vaccine, e.g. as cytolytic agent
C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
Applicants
  • MEDICAL RESEARCH COUNCIL [GB/GB]; 20 Park Crescent London W1N 4AL, GB (AllExceptUS)
  • THE WISTAR INSTITUTE [US/US]; 3601 Spruce Street Philadelphia, PA 19104-4268, US (AllExceptUS)
  • MACLEAN, Alasdair, Roderick [GB/GB]; GB (UsOnly)
  • BROWN, Susanne, Moira [GB/GB]; GB (UsOnly)
  • FRASER, Nigel, William [GB/US]; US (UsOnly)
  • RANDAZZO, Bruce, Paul [US/US]; US (UsOnly)
Inventors
  • MACLEAN, Alasdair, Roderick; GB
  • BROWN, Susanne, Moira; GB
  • FRASER, Nigel, William; US
  • RANDAZZO, Bruce, Paul; US
Agents
  • McCALLUM, William, Potter ; Cruikshank & Fairweather 19 Royal Exchange Square Glasgow G1 3AE, GB
Priority Data
9415320.229.07.1994GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TREATMENT OF CANCER USING HSV MUTANT
(FR) TRAITEMENT DU CANCER A L'AIDE D'UN MUTANT DU VIRUS DE L'HERPES (HSV)
Abstract
(EN)
Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the $g(g)34.5 gene in the long repeat region (RL) such that the $g(g)34.5 gene is non-functional, manufacture of medicaments and methods of testing cancer in mammals employing HSV mutant.
(FR)
L'invention se rapporte à l'utilisation d'un mutant du virus de l'herpès comme agent anticancéreux, mutant qui a été modifié dans le gène $g(g)34,5 de la région à longue répétition (RL) de sorte que le gène $g(g)34,5 ne soit pas fonctionnel, et à la fabrication de médicaments et à des procédés de dépistage du cancer chez des mammifères à l'aide du mutant du HSV.
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