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1. WO1996003979 - APPARATUS AND METHOD FOR PREPARING SOLID FORMS WITH CONTROLLED RELEASE OF THE ACTIVE INGREDIENT

Publication Number WO/1996/003979
Publication Date 15.02.1996
International Application No. PCT/IT1995/000048
International Filing Date 06.04.1995
IPC
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
B01J 2/04 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2Processes or devices for granulating materials, in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
02by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
04in a gaseous medium
B01J 2/18 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2Processes or devices for granulating materials, in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
18using a vibrating apparatus
CPC
A61K 9/1694
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1682Processes
1694resulting in granules or microspheres of the matrix type containing more than 5% of excipient
B01J 2/04
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2Processes or devices for granulating materials ; , e.g. fertilisers; in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
02by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
04in a gaseous medium
B01J 2/18
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2Processes or devices for granulating materials ; , e.g. fertilisers; in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
18using a vibrating apparatus
Applicants
  • SAITEC S.R.L. [IT/IT]; Via Arienti, 33 I-40124 Bologna, IT (AllExceptUS)
  • RODRIGUEZ, Lorenzo [IT/IT]; IT (UsOnly)
  • CINI, Maurizio [IT/IT]; IT (UsOnly)
  • CAVALLARI, Cristina [IT/IT]; IT (UsOnly)
  • MOTTA, Giuseppe [IT/IT]; IT (UsOnly)
Inventors
  • RODRIGUEZ, Lorenzo; IT
  • CINI, Maurizio; IT
  • CAVALLARI, Cristina; IT
  • MOTTA, Giuseppe; IT
Agents
  • LANZONI, Luciano; Bugnion S.p.A. Via dei Mille, 19 I-40121 Bologna, IT
Priority Data
BO94A00037903.08.1994IT
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) APPARATUS AND METHOD FOR PREPARING SOLID FORMS WITH CONTROLLED RELEASE OF THE ACTIVE INGREDIENT
(FR) APPAREIL ET PROCEDE DE PREPARATION DE FORMES SOLIDES A LIBERATION LENTE DU PRINCIPE ACTIF
Abstract
(EN)
An improved apparatus and method for preparing solid forms with controlled release of the active ingredient according to the spray drying and spray congealing techniques. The improvement involves the use of an atomizer utilizing the mechanical vibrations of resonant metal elements or nozzles so as to obtain very small droplets with very short spray length (25-30 cm). These droplets fall to give spherical powder particles owing to the evaporation of the contained solvents or of the quenching solidification of the melted waxy components.
(FR)
Appareil et procédé perfectionnés de préparation de formes solides à libération lente du principe actif, selon des techniques de séchage par pulvérisation et de congélation par pulvérisation. Le perfectionnement consiste à utiliser un atomiseur faisant appel aux vibrations mécaniques de buses ou d'éléments métalliques à résonance afin de produire de très petites gouttelettes avec une longueur de pulvérisation très faible (25-30 cm). Ces gouttelettes tombent pour produire des particules de poudre sphériques par évaporation des solvants qui y sont contenus ou par la solidification par refroidissement brusque des constituants fondus à base de cire.
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