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1. WO1996003978 - SOLID DELIVERY SYSTEMS FOR CONTROLLED RELEASE OF MOLECULES INCORPORATED THEREIN AND METHODS OF MAKING SAME

Publication Number WO/1996/003978
Publication Date 15.02.1996
International Application No. PCT/GB1995/001861
International Filing Date 04.08.1995
Chapter 2 Demand Filed 01.03.1996
IPC
A61K 9/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
CPC
A61K 9/0021
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
0021Intradermal administration, e.g. through microneedle arrays, needleless injectors
A61K 9/0036
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
0036Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
A61K 9/006
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0053Mouth and digestive tract, i.e. intraoral and peroral administration
006Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
A61K 9/0075
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
007Pulmonary tract; Aromatherapy
0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy;
0075for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
A61K 9/0092
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0087Galenical forms not covered by A61K9/02 - A61K9/7023
0092Hollow drug-filled fibres, tubes of the core-shell type, coated fibres, coated rods, microtubules, nanotubes
A61K 9/145
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
145with organic compounds
Applicants
  • QUADRANT HOLDINGS CAMBRIDGE LIMITED [GB/GB]; Maris Lane Trumpington Cambridge CB2 2SY, GB (AllExceptUS)
  • ROSER, Bruce, Joseph [GB/GB]; GB (UsOnly)
  • COLACO, Camilo [GB/GB]; GB (UsOnly)
  • JERROW, Mohamed, Abdel, Zahra [IQ/GB]; GB (UsOnly)
  • BLAIR, Julian, Alexander [GB/GB]; GB (UsOnly)
  • KAMPINGA, Jaap [NL/NL]; NL (UsOnly)
  • WARDELL, James, Lewis [GB/GB]; GB (UsOnly)
  • DUFFY, John, Alistair [GB/GB]; GB (UsOnly)
Inventors
  • ROSER, Bruce, Joseph; GB
  • COLACO, Camilo; GB
  • JERROW, Mohamed, Abdel, Zahra; GB
  • BLAIR, Julian, Alexander; GB
  • KAMPINGA, Jaap; NL
  • WARDELL, James, Lewis; GB
  • DUFFY, John, Alistair; GB
Agents
  • ABLEWHITE, Alan, James; Marks & Clerk 57-60 Lincoln's Inn Fields London WC2A 3LS, GB
Priority Data
08/349,02902.12.1994US
9415810.204.08.1994GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SOLID DELIVERY SYSTEMS FOR CONTROLLED RELEASE OF MOLECULES INCORPORATED THEREIN AND METHODS OF MAKING SAME
(FR) SYSTEMES D'ADMINISTRATION DE SUBSTANCES SOLIDES, POUR LA LIBERATION CONTROLEE DE MOLECULES INCORPOREES DANS CES SUBSTANCES ET PROCEDES DE FABRICATION DE CES SYSTEMES
Abstract
(EN)
The present invention encompasses solid dose delivery systems for administration of guest substances. Preferred delivery systems are suitable for delivery of bioactive materials to subcutaneous and intradermal, intramuscular, intravenous tissue, the delivery system being sized and shaped for penetrating the epidermis. The delivery systems comprise a vitreous vehicle loaded with the guest substance and capable of releasing the guest substance $i(in situ) at various controlled rates. The present invention further includes methods of making and using the solid dose delivery systems.
(FR)
Cette invention se rapporte à des systèmes d'apport de doses de substances solides, qui servent à l'administration de substances hôtes incorporées dans ces doses. Les systèmes d'administration préférés de cette invention se prêtent à l'apport de matières bioactives dans des tissus intraveineux, intramusculaires, sous-cutanés et intradermiques, la taille et la forme de ce système d'apport étant conçues pour lui permettre de pénétrer dans l'épiderme. Ces systèmes d'apport comprennent un excipient vitreux chargé de la substance hôte et capable de libérer cette substance hôte $i(in situ) à divers taux contrôlés. Cette invention se rapporte en outre à des procédés pour fabriquer et utiliser ces systèmes d'administration de doses de substances solides.
Also published as
CZPV1997-476
FI970867
NO19971688
SK199700277
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