Processing

Please wait...

Settings

Settings

1. WO1996003883 - CELLS BEARING CD4 DECOY RECEPTORS AND RELATED MOLECULES AND METHODS

Publication Number WO/1996/003883
Publication Date 15.02.1996
International Application No. PCT/US1995/009468
International Filing Date 26.07.1995
Chapter 2 Demand Filed 05.02.1996
IPC
A61K 35/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/725 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
725T-cell receptors
C07K 14/73 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
725T-cell receptors
73CD4
CPC
A61K 35/15
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
15Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
A61K 35/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
14Blood; Artificial blood
17Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/7051
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70503Immunoglobulin superfamily
7051T-cell receptor (TcR)-CD3 complex
C07K 14/70514
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70503Immunoglobulin superfamily
70514CD4
Applicants
  • THE GENERAL HOSPITAL CORPORATION [US/US]; 55 Fruit Street Boston, MA 02114, US
Inventors
  • SEED, Brian; US
  • BANAPOUR, Babak; US
  • ROMEO, Charles; US
  • KOLANUS, Waldemar; DE
Agents
  • LECH, Karen, F.; Fish & Richardson P.C. 225 Franklin Street Boston, MA 02110-2804, US
Priority Data
08/284,39102.08.1994US
08/394,38824.02.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CELLS BEARING CD4 DECOY RECEPTORS AND RELATED MOLECULES AND METHODS
(FR) CELLULES PORTANT DES RECEPTEURS LEURRES CD4 ET MOLECULES ET PROCEDES RELATIFS A CES CELLULES
Abstract
(EN)
Disclosed is a method of treating HIV in a mammal involving administering to the mammal an effective amount of therapeutic cells expressing a membrane-bound, proteinaceous chimeric receptor comprising an extracellular portion which includes a fragment of CD4 which is capable of specifically recognizing and binding the HIV-infected cell but which does not mediate HIV infection. Also disclosed are cells which express these CD4 receptors and DNA and vectors encoding the receptors.
(FR)
Procédé de traitement du VIH chez un mammifère, qui consiste à administrer à ce mammifère une quantité thérapeutiquement efficace de cellules thérapeutiques exprimant un récepteur chimérique protéique membranaire. Ledit récepteur comprend une partie extracellulaire qui comporte un fragment de CD4 capable de reconnaître spécifiquement la cellule infectée par le VIH et de se lier à cette dernière, mais qui n'induit pas l'infection due au VIH. Des cellules qui expriment ces récepteurs CD4 et de l'ADN et des vecteurs qui codent lesdits récepteurs sont également décrits.
Also published as
CZPV1997-264
FI970428
NO19970440
NZ291017
Other related publications
Latest bibliographic data on file with the International Bureau