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1. WO1996003652 - DETERMINATION OF A SPECIFIC IMMUNOGLOBULIN USING MULTIPLE ANTIGENS

Publication Number WO/1996/003652
Publication Date 08.02.1996
International Application No. PCT/EP1995/002919
International Filing Date 24.07.1995
Chapter 2 Demand Filed 14.12.1995
IPC
C07K 14/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
15Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
155Lentiviridae, e.g. human immunodeficiency virus (HIV), visna-maedi virus, equine infectious anaemia virus
16HIV-1
C07K 14/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
08RNA viruses
18Togaviridae, e.g. flavivirus, pestivirus, yellow fever virus, hepatitis C virus, japanese encephalitis virus
G01N 33/533 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
531Production of immunochemical test materials
532Production of labelled immunochemicals
533with fluorescent label
G01N 33/543 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
G01N 33/92 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
92involving lipids, e.g. cholesterol
CPC
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C12N 2740/16122
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2740Reverse Transcribing RNA Viruses
00011Reverse Transcribing RNA Viruses
10011Retroviridae
16011Human Immunodeficiency Virus, HIV
16111concerning HIV env
16122New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
C12N 2770/24222
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2770ssRNA Viruses positive-sense
00011ssRNA Viruses positive-sense
24011Flaviviridae
24211Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
24222New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
G01N 33/533
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
531Production of immunochemical test materials
532Production of labelled immunochemicals
533with fluorescent label
G01N 33/54306
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
54306Solid-phase reaction mechanisms
G01N 33/6878
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
6878in eptitope analysis
Applicants
  • BOEHRINGER MANNHEIM GMBH [DE/DE]; Sandhofer Strasse 112-132 D-68305 Mannheim, DE (AllExceptUS)
  • WIENHUES, Ursula-Henrike [DE/DE]; DE (UsOnly)
  • KRUSE-MÜLLER, Cornelia [DE/DE]; DE (UsOnly)
  • HÖSS, Eva [DE/DE]; DE (UsOnly)
  • FAATZ, Elke [DE/DE]; DE (UsOnly)
  • OFENLOCH-HÄHNLE, Beatus [DE/DE]; DE (UsOnly)
  • SEIDEL, Christoph [DE/DE]; DE (UsOnly)
  • WIEDMANN, Michael [DE/DE]; DE (UsOnly)
Inventors
  • WIENHUES, Ursula-Henrike; DE
  • KRUSE-MÜLLER, Cornelia; DE
  • HÖSS, Eva; DE
  • FAATZ, Elke; DE
  • OFENLOCH-HÄHNLE, Beatus; DE
  • SEIDEL, Christoph; DE
  • WIEDMANN, Michael; DE
Agents
  • WEICKMANN, H. ; Kopernikusstrasse 9 D-81679 München, DE
Priority Data
P 44 26 276.025.07.1994DE
P 44 30 972.431.08.1994DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) BESTIMMUNG VON SPEZIFISCHEM IMMUNGLOBULIN UNTER VERWENDUNG MULTIPLER ANTIGENE
(EN) DETERMINATION OF A SPECIFIC IMMUNOGLOBULIN USING MULTIPLE ANTIGENS
(FR) DOSAGE D'UNE IMMUNOGLOBULINE SPECIFIQUE A L'AIDE DE MULTIPLES ANTIGENES
Abstract
(DE)
Die Erfindung betrifft ein Verfahren zur immunologischen Bestimmung eines spezifischen Antikörpers in einer Probeflüssigkeit, wobei man die Probeflüssigkeit in Gegenwart einer Festphase mit zwei gegen den zu bestimmenden Antikörper gerichteten Antigenen inkubiert, wobei das erste Antigen mindestens eine Markierungsgruppe trägt und das zweite Antigen (a) an die Festphase gebunden ist oder (b) in einer an die Festphase bindefähigen Form vorliegt, und den zu bestimmenden Antikörper durch Bestimmung der Markierungsgruppe in der Festphase oder/und in der flüssigen Phase nachweist, welches dadurch gekennzeichnet ist, daß mindestens eines der beiden Antigene mehrere Epitopbereiche umfaßt, die mit dem zu bestimmenden Antikörper reagieren.
(EN)
The invention concerns a process for the immunological determination of a specific antibody in a fluid sample. The process involves incubating the fluid sample in the presence of a solid phase with two antigens directed against the antibody whose presence is to be determined; the first antigen carries at least one marker group, while the second is either (a) bonded to the solid phase or (b) present in a form in which it can bond with the solid phase, and betrays the presence of the antibody being sought by showing the presence of the marker group in the solid phase and/or in the fluid phase. The proposed process is characterised by the fact that at least one of the two antigens has several epitopic regions which react with the antibody to be determined.
(FR)
L'invention concerne un procédé pour le dosage immunologique d'un anticorps spécifique dans un échantillon de liquide. Ce procédé consiste à incuber l'échantillon de liquide en présence d'une phase solide avec deux antigènes dirigés contre l'anticorps à doser; le premier antigène porte au moins un groupe marqueur, tandis que le second est soit (a) lié à la phase solide ou (b) présent sous une forme dans laquelle il peut se lier à la phase solide, et décèle l'anticorps à doser par recherche du groupe marqueur dans la phase solide et/ou dans la phase liquide. Le procédé décrit est caractérisé en ce qu'au moins un des deux antigènes comporte plusieurs régions d'épitope qui réagissent avec l'anticorps à doser.
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