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1. WO1996003649 - Src SH3 BINDING PEPTIDES AND METHODS OF ISOLATING AND USING SAME

Publication Number WO/1996/003649
Publication Date 08.02.1996
International Application No. PCT/US1995/009382
International Filing Date 24.07.1995
Chapter 2 Demand Filed 20.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C07K 7/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
C07K 7/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
C07K 14/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C07K 14/435 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 47/62
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
62the modifying agent being a protein, peptide or polyamino acid
C07K 14/001
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
001by chemical synthesis
C07K 14/435
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
C07K 7/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
06having 5 to 11 amino acids
Applicants
  • THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL [US/US]; Office of Technology Development CB #4100, 302 Bynum Hall Chapel Hill, NC 27599-4100, US
Inventors
  • SPARKS, Andrew, B.; US
  • KAY, Brian, K.; US
  • THORN, Judith, M.; US
  • QUILLIAM, Lawrence, A.; US
  • DER, Channing, J.; US
Agents
  • MISROCK, S., Leslie ; Pennie & Edmonds 1155 Avenue of the Americas New York, NY 10036, US
Priority Data
278,86522.07.1994US
483,55507.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) Src SH3 BINDING PEPTIDES AND METHODS OF ISOLATING AND USING SAME
(FR) PEPTIDES SE FIXANT AUX SH3 DE Src ET LEURS METHODES D'ISOLEMENT ET D'UTILISATION
Abstract
(EN)
Peptides having general and specific binding affinities for the Src homology region 3 (SH3) domains of proteins are disclosed in the present invention. In particular, SH3 binding peptides have been isolated from three phage-displayed random peptide libraries which had been screened for isolates that bind to bacterial fusion proteins comprising SH3 and glutathione S-transferase (GST). Preferred peptides are disclosed which comprise a core 7-mer sequence (preferably, a consensus motif) and two or more, preferably at least six, additional amino acid residues flanking the core sequence, for a total length of 9, preferably at least 13, amino acid residues and no more than about 45 amino acid residues. Such peptides manifest preferential binding affinities for certain SH3 domains. The preferred peptides exhibit specific binding affinities for the Src-family of proteins. $i(In vitro) and $i(in vivo) results are presented which demonstrate the biochemical activity of such peptides.
(FR)
L'invention porte sur des peptides présentant des affinités de fixation générales et spécifiques pour les domaines SH3 (région 3 d'homologie des protéines Src). En particulier des peptides se fixant aux SH3 ont été isolés à partir de trois banques de peptides aléatoires de phages qui ont été triées pour y détecter des isolats se fixant à des protéines obtenues par fusion bactérienne comprenant les SH3 et la glutathione S-transférase (GST). Les peptides préférés présentés comprennent une séquence c÷ur à 7-mer (de préférence à motif consensus) et deux ou plus, et de préférence au moins 6, résidus additionnels d'acides aminés qui flanquent la séquence c÷ur, ce qui donne une longueur totale de 9, et de préférence d'au moins 13 et d'au plus 45, résidus d'acides aminés. Ces peptides manifestent des affinités de fixation préférentielles pour certains domaines SH3, et les peptides préférés présentent des affinités de fixation spécifiques pour les protéines de la famille Src. Des résultats obtenus $i(in vitro) et $i(in vivo) présentés ici démontrent l'activité biochimique de ces peptides.
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