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1. WO1996003647 - METHOD FOR SCREENING COMPOUND LIBRARIES

Publication Number WO/1996/003647
Publication Date 08.02.1996
International Application No. PCT/GB1995/001700
International Filing Date 19.07.1995
Chapter 2 Demand Filed 27.12.1995
IPC
G01N 33/50 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G01N 33/543 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 33/58 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58involving labelled substances
CPC
G01N 33/50
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 33/582
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58involving labelled substances
582with fluorescent label
Applicants
  • ZENECA LIMITED [GB/GB]; 15 Stanhope Gate London W1Y 6LN, GB (AllExceptUS)
  • GARMAN, Andrew, John [GB/GB]; GB (UsOnly)
  • HOLLAND, Janet, Dora [GB/GB]; GB (UsOnly)
Inventors
  • GARMAN, Andrew, John; GB
  • HOLLAND, Janet, Dora; GB
Agents
  • PHILLIPS, Neil, Godfrey, Alasdair; Zeneca Pharmaceuticals Intellectual Property Group Intellectual Property Dept. Mereside, Alderley Park Macclesfield, Cheshire SK10 4TG, GB
Priority Data
9410137.419.05.1995GB
9414770.922.07.1994GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR SCREENING COMPOUND LIBRARIES
(FR) PROCEDE DE CRIBLAGE DE BANQUES DE COMPOSES
Abstract
(EN)
A method for screening a compound library provided on solid phase, which method comprises releasing a proportion of the library from the solid phase into distinct zones of an assay medium, performing a proximity screening assay with a biological of interest within the medium, identifying active zone(s) in the assay medium and determining the identity of active member(s) of the library by reference to the corresponding compound(s) still bound to the solid phase.
(FR)
Procédé de criblage d'une banque de composés obtenus sur phase solide, consistant à libérer de cette phase, dans des zones distinctes d'un milieu de titrage, une proportion de la banque, à effectuer dans ce milieu un titrage du criblage de proximité à l'aide d'un agent biologique d'intérêt, à identifier la (les) zone(s) active(s) dans le milieu de titrage et à déterminer l'identité du (des) membre(s) actif(s) de la banque par référence au(x) composé(s) correspondant(s) encore lié(s) à la phase solide.
Also published as
Latest bibliographic data on file with the International Bureau