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1. WO1996003524 - DIAGNOSTIC METHOD

Publication Number WO/1996/003524
Publication Date 08.02.1996
International Application No. PCT/AU1995/000452
International Filing Date 25.07.1995
Chapter 2 Demand Filed 23.02.1996
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/683
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6813Hybridisation assays
6827for detection of mutation or polymorphism
683involving restriction enzymes, e.g. restriction fragment length polymorphism [RFLP]
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/156
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
C12Q 2600/172
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
172Haplotypes
Applicants
  • GARVAN INSTITUTE OF MEDICAL RESEARCH [AU/AU]; C/o St Vincents Hospital 384 Victoria Street Darlinghurst, NSW 2010, AU (AllExceptUS)
  • MORRISON, Nigel, Alexander [AU/AU]; AU (UsOnly)
  • EISMAN, John, Allan [AU/AU]; AU (UsOnly)
  • KELLY, Paul, James [AU/AU]; AU (UsOnly)
Inventors
  • MORRISON, Nigel, Alexander; AU
  • EISMAN, John, Allan; AU
  • KELLY, Paul, James; AU
Agents
  • F.B. RICE & CO.; 28A Montague Street Balmain, NSW 2041, AU
Priority Data
PM 701525.07.1994AU
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DIAGNOSTIC METHOD
(FR) PROCEDE DE DIAGNOSTIC
Abstract
(EN)
The present invention provides a method of assessing an individual's predisposition to low or high bone density and/or risk of fracture comprising assessing the vitamin D receptor genotype of the individual by haplotype analysis. Preferably the genotype of the individual is assessed by haplotype analysis by assessing the genotype for the polymorphic restriction endonuclease sites for Bsm-1, Apa-1 and Taq-1 in the combinations of Bsm-1 and Apa-1, or Taq-1 and Apa-1, or Bsm-1 and Taq-1, or Bsm-1, Apa-1 and Taq-1.
(FR)
Procédé permettant de déterminer la prédisposition d'un individu à développer une faible ou une forte densité osseuse et/ou le risque de fractures, consistant à déterminer le génotype du récepteur de vitamine D de cet individu par analyse de l'haplotype. De préférence, la détermination du génotype dudit individu par analyse de l'haplotype consiste à déterminer le génotype pour les sites d'endonucléase de restriction polymorphe pour Bsm-1, Apa-1 et Taq-1 dans les combinaisons de Bsm-1 et Apa-1, ou Taq-1 et Apa-1, ou Bsm-1 et Taq-1, ou Bsm-1, Apa-1 et Taq-1.
Also published as
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