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1. WO1996003507 - METHOD OF ISOLATING ATTENUATED VIRUS AND VACCINE THEREOF

Publication Number WO/1996/003507
Publication Date 08.02.1996
International Application No. PCT/GB1995/001749
International Filing Date 24.07.1995
Chapter 2 Demand Filed 02.02.1996
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/01 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
01DNA viruses
CPC
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/005
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
C12N 2750/12022
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2750ssDNA Viruses
00011ssDNA Viruses
12011Geminiviridae
12022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
C12N 2750/12061
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2750ssDNA Viruses
00011ssDNA Viruses
12011Geminiviridae
12061Methods of inactivation or attenuation
Applicants
  • MALLINCKRODT VETERINARY, INC. [US/US]; 421 East Hawley Street Mundelein, IL 60060, US (AllExceptUS)
  • TODD, Daniel [GB/GB]; GB (UsOnly)
  • McNULTY, M., Stewart [GB/GB]; GB (UsOnly)
Inventors
  • TODD, Daniel; GB
  • McNULTY, M., Stewart; GB
Agents
  • MURGITROYD & COMPANY; 373 Scotland Street Glasgow G5 8QA, GB
Priority Data
9414888.923.07.1994GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD OF ISOLATING ATTENUATED VIRUS AND VACCINE THEREOF
(FR) PROCEDE D'ISOLEMENT DE VIRUS ATTENUE ET VACCIN ASSOCIE
Abstract
(EN)
The present invention provides a method of separating a virus isolate, in particular an attenuated virus isolate, form a mixed pool of viruses. In the method the viral genetic information is cloned into a vector, thus creating a vector library of the viral pool. The verctors are used to transfect host cells which are then grown up and separated into individual clones. The virus isolate required can be reconstituted from the relevant transformed clone. Using this technique with respect to Chicken Anaemia Virus an attenuated virus was isolate. The invention provides this isolate, the genetic sequence of this isolated and a vaccine against Chicken Anaemia Virus.
(FR)
Procédé utilisé pour séparer un isolat viral notamment un isolat de virus atténué, se trouvant dans un ensemble mélangé de virus. Dans ce procédé, on clone les informations génétiques virales dans un vecteur, ce qui crée une banque de vecteurs de l'ensemble des virus. On utilise lesdits vecteurs pour transfecter des cellules hôtes qui sont ensuite cultivées et séparées en clones individuels. On peut reconstituer l'isolat viral nécessaire à partir du clone transformé approprié. A l'aide de cette technique, on a isolé un virus atténué en rapport avec le virus de l'anémie infectieuse du poulet. Cette invention concerne cet isolat, la séquence génétique dudit isolat et un vaccin contre le virus de l'anémie infectieuse du poulet.
Also published as
Latest bibliographic data on file with the International Bureau