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Machine translation
1. (WO1996003506) ANALOG OF HAEMOPHILUS HIN47 WITH REDUCED PROTEASE ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/003506    International Application No.:    PCT/CA1995/000434
Publication Date: 08.02.1996 International Filing Date: 21.07.1995
IPC:
A61K 39/00 (2006.01), C07K 14/285 (2006.01), C12N 9/52 (2006.01)
Applicants: CONNAUGHT LABORATORIES LIMITED [CA/CA]; 1755 Steeles Avenue West, Willowdale, Ontario M2R 3T4 (CA) (For All Designated States Except US).
LOOSMORE, Sheena, M. [CA/CA]; (CA) (For US Only).
YANG, Yan-Ping [CN/CA]; (CA) (For US Only).
CHONG, Pele [CA/CA]; (CA) (For US Only).
OOMEN, Raymond, P. [CA/CA]; (CA) (For US Only).
KLEIN, Michel, H. [CA/CA]; (CA) (For US Only)
Inventors: LOOSMORE, Sheena, M.; (CA).
YANG, Yan-Ping; (CA).
CHONG, Pele; (CA).
OOMEN, Raymond, P.; (CA).
KLEIN, Michel, H.; (CA)
Agent: STEWART, Michael, I.; Sim & McBurney, Suite 701, 330 University Avenue, Toronto, Ontario M5G 1R7 (CA)
Priority Data:
08/278,091 21.07.1994 US
08/296,149 26.08.1994 US
08/487,167 07.06.1995 US
Title (EN) ANALOG OF HAEMOPHILUS HIN47 WITH REDUCED PROTEASE ACTIVITY
(FR) ANALOGUE D'HAEMOPHILUS HIN47 A ACTIVITE PROTEASE REDUITE
Abstract: front page image
(EN)The invention concerns isolated and purified analogs of $i(Haemophilus influenza) Hin47 protein with decreased protease activity (of less than 10 % of that of the natural protein) but preferably retaining substantially the same immunogenic properties as natural Hin47. Preferred analogs have mutations at Ser197, His91 and/or Asp121 positions and are possibly used as chimeric proteins with other immunogenic molecules. Also disclosed are nucleic acid encoding said analogs, recombinant plasmids and transformed host cells containing said modified genes, immunogenic compositions containing Hin47 analogs or their nucleic acid and their use for prophylactic, vaccine or diagnostic purposes.
(FR)Analogues isolés et purifiés de la protéine $i(Haemophilus influenzae) Hin47 présentant une activité protéase réduite (inférieure à environ 10 % de celle de la protéine naturelle) et de préférence sensiblement les mêmes propriétés immunogènes que la Hin47 naturelle. Les analogues préférés présentent des mutations au niveau des positions Ser197, His91 et/ou Asp121, et peuvent être utilisés comme des protéines chimères avec d'autres molécules immunogènes. L'invention porte également sur un acide nucléique codant lesdits analogues, des plasmides recombinés et des cellules hôtes transformées contenant ledits gènes modifiés, des compositions immunogènes comprenant les analogues de Hin47 ou leur acide nucléique ainsi que sur leur utilisation à des fins prophylactiques, diagnostiques ou de vaccination.
Designated States: AM, AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, JP, KE, KG, KP, KR, KZ, LK, LR, LT, LU, LV, MD, MG, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SI, SK, TJ, TT, UA, US, UZ, VN.
African Regional Intellectual Property Organization (KE, MW, SD, SZ, UG)
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)