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1. WO1996003497 - NOVEL HYALURONIDASE

Publication Number WO/1996/003497
Publication Date 08.02.1996
International Application No. PCT/JP1995/001452
International Filing Date 21.07.1995
Chapter 2 Demand Filed 08.01.1996
IPC
C12N 9/26 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14Hydrolases (3.)
24acting on glycosyl compounds (3.2)
26acting on alpha-1, 4-glucosidic bonds, e.g. hyaluronidase, invertase, amylase
C12N 9/88 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
88Lyases (4.)
CPC
C12N 9/2408
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
14Hydrolases (3)
24acting on glycosyl compounds (3.2)
2402hydrolysing O- and S- glycosyl compounds (3.2.1)
2405Glucanases
2408acting on alpha -1,4-glucosidic bonds
C12N 9/88
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
88Lyases (4.)
Applicants
  • SEIKAGAKU CORPORATION [JP/JP]; 1-5, Nihonbashi-Honcho 2-chome Chuo-ku Tokyo 103, JP (AllExceptUS)
  • YAMAGATA, Tatsuya [JP/JP]; JP (UsOnly)
  • MIURA, Ryu [JP/JP]; JP (UsOnly)
  • YAMAGATA, Sadako [JP/JP]; JP (UsOnly)
Inventors
  • YAMAGATA, Tatsuya; JP
  • MIURA, Ryu; JP
  • YAMAGATA, Sadako; JP
Agents
  • HAGINO, Taira ; Eikoh Patent Office ARK Mori Building, 28th floor 12-32, Akasaka 1-chome Minato-ku Tokyo 107, JP
Priority Data
6/17120622.07.1994JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) NOVEL HYALURONIDASE
(FR) NOUVELLE HYALURONIDASE
Abstract
(EN)
A novel hyaluronidase (HAase) isolated from a supernatant of a human uterine body cancer tissue culture by means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis using hyaluronic acid, modified chondroitin sulfate or the like as the substrate. The obtained HAase hydrolyzes hyaluronic acid at a pH of 3.5 to 7.5, but not chondroitin sulfate, and is useful for, for example, searching remedies for cerebral edema, myocardial infarct and the like, drug additives, and hyaluronidase inhibitors.
(FR)
Une nouvelle hyaluronidase (HAase) est isolée du surnageant d'une culture de tissu cancéreux de l'utérus humain par une électrophorèse sur un gel de dodécyle sulfate de sodium et de polyacrylamide en utilisant de l'acide hyaluronique, un sulfate de chondroïtine modifié ou similaire comme substrat. La HAase obtenue hydrolyse l'acide hyaluronique à un pH de 3,5 à 7,5, mais pas le sulfate de chondroïtine et elle est utile, par exemple, pour la mise au point de remèdes contre les ÷dèmes cérébraux, l'infarctus du myocarde et similaire, comme adjuvant pour des médicaments et comme inhibiteur de la hyaluronidase.
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