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1. WO1996003430 - ORGANIC COMPOUNDS

Publication Number WO/1996/003430
Publication Date 08.02.1996
International Application No. PCT/EP1995/002966
International Filing Date 26.07.1995
Chapter 2 Demand Filed 13.01.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 11/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
11Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
02cyclic, e.g. valinomycins
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
Applicants
  • SANDOZ LTD. [CH]/[CH] (AM, AT, AU, BB, BE, BF, BG, BJ, BR, BY, CA, CF, CG, CH, CI, CM, CN, CZ, DE, DK, EE, ES, FI, FR, GA, GB, GE, GN, GR, HU, IE, IS, IT, JP, KE, KG, KP, KR, KZ, LK, LR, LT, LU, LV, MC, MD, MG, ML, MN, MR, MW, MX, NE, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, SN, SZ, TD, TG, TJ, TM, TT, UA, UG, UZ, VN)
  • SANDOZ-PATENT-GMBH [DE]/[DE] (DE)
  • SANDOZ-ERFINDUNGEN VERWALTUNGSGESELLSCHAFT M.B.H. [AT]/[AT] (AT)
  • DREYFUSS, Michael, Morris [US]/[CH] (UsOnly)
  • FOSTER, Carolyn, Ann [US]/[AT] (UsOnly)
  • NAEGELI, Hans-Ulrich [CH]/[CH] (UsOnly)
  • OBERHAUSER, Berndt [AT]/[AT] (UsOnly)
Inventors
  • DREYFUSS, Michael, Morris
  • FOSTER, Carolyn, Ann
  • NAEGELI, Hans-Ulrich
  • OBERHAUSER, Berndt
Common Representative
  • SANDOZ LTD.
Priority Data
9415168.527.07.1994GB
9504332.903.03.1995GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ORGANIC COMPOUNDS
(FR) COMPOSES ORGANIQUES
Abstract
(EN)
Cyclopeptolides of formula (I) wherein A, B, R1Leu, Leu, C, X and Y are as defined, are inhibitors of adhesion molecule expression and are thus useful for treatment of inflammatory and other diseases which involve increased levels of adhesion molecule expression.
(FR)
Des cyclopeptolides de formule (I), dans laquelle A, B, R1Leu, Leu, C, X et Y sont définis dans le descriptif de l'invention, sont des inhibiteurs de l'expression des molécules d'adhérence et servent, par conséquent, dans le traitement de maladies inflammatoires et autres comportant l'accroissement du degré d'expression des molécules d'adhérence.
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