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1. WO1996003428 - ANTIPROTOZOAL CYCLIC TETRAPEPTIDES

Publication Number WO/1996/003428
Publication Date 08.02.1996
International Application No. PCT/US1995/009371
International Filing Date 24.07.1995
Chapter 2 Demand Filed 08.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
12Cyclic peptides
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/126
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
12Cyclic peptides ; with only normal peptide bonds in the ring
126Tetrapeptides
C12R 1/77
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
RPROCESSES USING MICROORGANISMS
1Processes using microorganisms
645using fungi
77Fusarium
Y02A 50/411
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
50in human health protection
30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
38Medical treatment of vector-borne diseases characterised by the agent
408the vector-borne disease being caused by a protozoa
411of the genus Plasmodium, i.e. Malaria
Applicants
  • MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065, US (AllExceptUS)
  • CANNOVA, Christine, Lange [US/US]; US (UsOnly)
  • DOMBROWSKI, Anne, W. [US/US]; US (UsOnly)
  • GOETZ, Michael, A. [US/US]; US (UsOnly)
  • RATTRAY, Sandra, J. [NZ/US]; US (UsOnly)
  • SINGH, Sheo, Bux [IN/US]; US (UsOnly)
  • POLISHOOK, Jon [US/US]; US (UsOnly)
  • BILLS, Gerald, F. [US/US]; US (UsOnly)
  • GREENE, Joyce, A. [US/US]; US (UsOnly)
  • DARLAND, Gary, K. [US/US]; US (UsOnly)
Inventors
  • CANNOVA, Christine, Lange; US
  • DOMBROWSKI, Anne, W.; US
  • GOETZ, Michael, A.; US
  • RATTRAY, Sandra, J.; US
  • SINGH, Sheo, Bux; US
  • POLISHOOK, Jon; US
  • BILLS, Gerald, F.; US
  • GREENE, Joyce, A.; US
  • DARLAND, Gary, K.; US
Common Representative
  • MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065, US
Priority Data
281,32527.07.1994US
447,66423.05.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTIPROTOZOAL CYCLIC TETRAPEPTIDES
(FR) TETRAPEPTIDES CYCLIQUES ANTIPROTOZOAIRES
Abstract
(EN)
The present invention provides novel cyclic tetrapeptides useful in the treatment or prevention of protozoal diseases; in particular, the novel compounds are active against the causative pathogens in malaria, toxoplasmosis, and coccidiosis.
(FR)
L'invention porte sur de nouveaux tétrapeptides cycliques servant dans le traitement des maladies dues aux protozoaires et s'avérant actifs contre les agents pathogènes cause de la malaria, de la toxoplasmose et de la coccidiose.
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