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Machine translation
1. (WO1996003425) PROCESS FOR FOLDING OF PROTEINS LIKE RECOMBINANT HIRUDIN OR EPIDERMAL GROWTH FACTOR
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/003425    International Application No.:    PCT/EP1995/002720
Publication Date: 08.02.1996 International Filing Date: 12.07.1995
Chapter 2 Demand Filed:    13.01.1996    
IPC:
A61K 38/00 (2006.01), C07K 1/113 (2006.01), C07K 14/485 (2006.01), C07K 14/815 (2006.01)
Applicants: CIBA-GEIGY AG [CH/CH]; Klybeckstrasse 141, CH-4002 Basle (CH) (For All Designated States Except US).
CHANG, Jui, Yoa [--/CH]; (CH) (For US Only)
Inventors: CHANG, Jui, Yoa; (CH)
Common
Representative:
CIBA-GEIGY AG; Patentabteilung, Klybeckstrasse 141, CH-4002 Basle (CH)
Priority Data:
94810437.7 25.07.1994 EP
Title (EN) PROCESS FOR FOLDING OF PROTEINS LIKE RECOMBINANT HIRUDIN OR EPIDERMAL GROWTH FACTOR
(FR) PROCEDE DE REPLIEMENT DE PROTEINES TELLES QUE L'HIRUDINE OU LE FACTEUR DE CROISSANCE EPIDERMIQUE DE RECOMBINAISON
Abstract: front page image
(EN)The invention relates to a process for the preparation of a biologically active and correctly folded protein in the presence of a denaturing agent like urea or guanidine hydrochloride and the separation of the correctly folded protein therefrom directly. This process can be applied, for example, in the renaturation of recombinant proteins like hirudin or epidermal growth factor.
(FR)L'invention concerne un procédé permettant de préparer une protéine repliée correctement, biologiquement active, en présence d'un agent dénaturant tel que l'urée ou l'hydrochlorure de guanidine, et de séparer la protéine correctement repliée directement de celui-ci. Ce procédé peut être mis en ÷uvre, par exemple, lors de la renaturation de protéines de recombinaison telles que l'hirudine ou le facteur de croissance épidermique.
Designated States: AM, AU, BB, BG, BR, BY, CA, CN, CZ, EE, FI, GE, HU, IS, JP, KG, KP, KR, KZ, LK, LR, LT, LV, MD, MG, MN, MX, NO, NZ, PL, RO, RU, SG, SI, SK, TJ, TM, TT, UA, US, UZ, VN.
African Regional Intellectual Property Organization (KE, MW, SD, SZ, UG)
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)