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1. WO1996003424 - COMBINATORIAL LIBRARIES OF MOLECULES AND METHODS FOR PRODUCING SAME

Publication Number WO/1996/003424
Publication Date 08.02.1996
International Application No. PCT/US1995/009541
International Filing Date 26.07.1995
Chapter 2 Demand Filed 21.02.1996
IPC
C07D 207/327 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30having two double bonds between ring members or between ring members and non-ring members
32with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
325with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
327Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 209/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
C07D 241/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02not condensed with other rings
10having three double bonds between ring members or between ring members and non-ring members
12with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07H 21/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C07K 1/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General processes for the preparation of peptides
04on carriers
CPC
C07D 207/327
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
207Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
02with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
30having two double bonds between ring members or between ring members and non-ring members
32with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
325with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
327Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 209/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
209Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02condensed with one carbocyclic ring
04Indoles; Hydrogenated indoles
C07D 241/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
241Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
02not condensed with other rings
10having three double bonds between ring members or between ring members and non-ring members
12with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C07K 1/047
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
1General methods for the preparation of peptides ; , i.e. processes for the organic chemical preparation of peptides or proteins of any length
04on carriers
047Simultaneous synthesis of different peptide species; Peptide libraries
Applicants
  • THE SCRIPPS RESEARCH INSTITUTE [US/US]; 10666 North Torrey Pines Road La Jolla, CA 92037, US (AllExceptUS)
  • BOGER, Dale, L. [US/US]; US (UsOnly)
Inventors
  • BOGER, Dale, L.; US
Agents
  • WEISS, Steven, M. ; Lyon & Lyon Suite 4700 633 West Fifth Street Los Angeles, CA 90071-2066, US
  • WARBURG, Richard, J; LYON & LYON Suite 4700 633 West Fith Street, Los Angeles, CA 90071-2066, US
Priority Data
08/281,19626.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMBINATORIAL LIBRARIES OF MOLECULES AND METHODS FOR PRODUCING SAME
(FR) BIBLIOTHEQUES COMBINATOIRES DE MOLECULES ET PROCEDES DE PRODUCTION DES MEMES
Abstract
(EN)
This invention features methods of synthesizing combinatorial libraries of chemical compounds, and combinatorial libraries of chemical compounds formed by the methods of this invention. Specifically, Diels-Alder chemistry is utilized to generate libraries of diverse molecules which are easily differentially functionalized with various chemical moities and in one aspect are configured to act as non-hydrolyzable peptidomimetics.
(FR)
La présente invention concerne, d'une part des procédés de synthèse de bibliothèques combinatoires de composés chimiques, et d'autre part des bibliothèques combinatoires constituées selon les procédés de la présente invention. En l'occurrence, on a eu recours à la chimie de Diels-Alder pour générer des bibliothèques de diverses molécules facilement fonctionnalisables de façon différentielle grâce à différentes fractions chimiques et qui sont configurées pour se comporter comme des peptidomimétiques non hydrolysables.
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