Processing

Please wait...

Settings

Settings

1. WO1996003421 - NEUROLOGICALLY ACTIVE AMINOSTEROIDS

Publication Number WO/1996/003421
Publication Date 08.02.1996
International Application No. PCT/US1995/008646
International Filing Date 18.07.1995
Chapter 2 Demand Filed 05.02.1996
IPC
A61K 31/58 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopentahydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
58containing heterocyclic rings, e.g. aldosterone, danazol, stanozolol, pancuronium, digitogenin
C07J 5/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
5Normal steroids containing carbon, hydrogen, halogen, or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane, and substituted in position 21 by only one singly bound oxygen atom
C07J 43/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
43Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopentahydrophenanthrene skeleton
CPC
A61K 31/58
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives, e.g. steroids
58containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
C07J 43/003
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
43Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
003not condensed
C07J 5/003
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
5Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, ; i.e. only one oxygen bound to position 21 by a single bond
0007not substituted in position 17 alfa
0023substituted in position 16
003by a saturated or unsaturated hydrocarbon group including 16-alkylidene substitutes
Applicants
  • PHARMACIA & UPJOHN COMPANY [US/US]; 301 Henrietta Street Kalamazoo, MI 49001, US (AllExceptUS)
  • JACOBSEN, Eric, Jon [US/US]; US (UsOnly)
  • BUNDY, Gordon, L. [US/US]; US (UsOnly)
  • WYNALDA, Michael, A. [US/US]; US (UsOnly)
Inventors
  • JACOBSEN, Eric, Jon; US
  • BUNDY, Gordon, L.; US
  • WYNALDA, Michael, A.; US
Agents
  • STEIN, Bruce; Pharmacia & Upjohn Company Corporate Intellectual Property Law 301 Henrietta Street Kalamazoo, MI 49001, US
  • PERRY, Robert, Edward; Gill Jennings & Every Broadgate House 7 Eldon Street London EC2M 7LH, GB
Priority Data
08/278,63321.07.1994US
08/361,81822.12.1994US
08/473,87307.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NEUROLOGICALLY ACTIVE AMINOSTEROIDS
(FR) AMINOSTEROIDES ACTIFS AU NIVEAU NEUROLOGIQUE
Abstract
(EN)
6$g(a)-Hydroxy-21-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl]-16$g(a)-methylpregna-1,4,9(11)-triene-3,20-dione, 6$g(b)-hydroxy-21-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl]-16$g(a)-methylpregna-1,4,9(11)-triene-3,20-dione, 21-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl]-16$g(a)-methyl-5$g(a)-pregna-1,9(11)-diene-3,20-dione and 21-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-1-piperazinyl]-16$g(a)-methyl-5$g(b)-pregna-1,9(11)-diene-3,20-dione and pharmaceutically acceptable salts thereof are neurologically active steroids.
(FR)
Les 6$g(a)-hydroxy-21-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-1-pipérazinyl]-16$g(a)-méthylprégna-1,4,9(11)-triène-3,20-dione, 6$g(b)-hydroxy-21-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-1-pipérazinyl]-16$g(a)méthylprégna-1,4,9(11)-triène-3,20-dione, 21-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-1-pipérazinyl]-16$g(a)-méthyl-5$g(a)-prégna-1,9(11)-diène-3,20-dione et 21-[4-[2,6-bis(1-pyrrolidinyl)-4-pyrimidinyl]-1-pipérazinyl]-16$g(a)-méthyl-5$g(b)-prégna-1,9(11)-diène-3,20-dione ainsi que leurs sels acceptables sur le plan pharmaceutique sont des stéroïdes actifs au niveau neurologique.
Also published as
EP1995927131
Latest bibliographic data on file with the International Bureau