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1. WO1996003415 - HUMAN POTASSIUM CHANNEL 1 AND 2 PROTEINS

Publication Number WO/1996/003415
Publication Date 08.02.1996
International Application No. PCT/US1994/008449
International Filing Date 28.07.1994
Chapter 2 Demand Filed 30.01.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 11/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
11Drugs for disorders of the respiratory system
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C12N 2799/026
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2799Uses of viruses
02as vector
021for the expression of a heterologous nucleic acid
026where the vector is derived from a baculovirus
Applicants
  • HUMAN GENOME SCIENCES, INC. [US/US]; Suite 300 9620 Medical Center Drive Rockville, MD 20850-3338, US (AllExceptUS)
  • LI, Yi [CN/US]; US (UsOnly)
  • ADAMS, Mark, D. [US/US]; US (UsOnly)
  • WHITE, Owen, R. [US/US]; US (UsOnly)
Inventors
  • LI, Yi; US
  • ADAMS, Mark, D.; US
  • WHITE, Owen, R.; US
Agents
  • OLSTEIN, Elliot, M., ; Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein 6 Becker Farm Road Roseland, NJ 07068, US
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HUMAN POTASSIUM CHANNEL 1 AND 2 PROTEINS
(FR) PROTEINES HUMAINES 1 ET 2 DES CANAUX POTASSIQUES
Abstract
(EN)
Disclosed are human K+ channel polypeptides and DNA (RNA) encoding such K+ channel polypeptides. Also provided is a procedure for producing such polypeptides by recombinant techniques. Agonists for such K+ channel polypeptides are also disclosed. Such agonists may be used to treat epilepsy, stroke, hypertension, asthma, Parkinson's disease, schizophrenia, anxiety, depression and neurodegeneration. Also disclosed are antagonists against such polypeptides which may be used to treat AIDS, SLE, diabetes, multiple sclerosis and cancer.
(FR)
L'invention se rapporte à des polypeptides humains des canaux K+ et à l'ADN (ARN) codant ces polypeptides des canaux K+. L'invention se rapporte également à un procédé de production de ces polypeptides par des techniques de recombinaison. Les agonistes de ces polypeptides des canaux K+ sont également décrits. Ils peuvent être utilisés pour traiter l'épilepsie, les attaques, l'hypertension, l'asthme, la maladie de Parkinson, la schizophrénie, l'anxiété, la dépression et la neurodégénérescence. Des antagonistes contre ces polypeptides sont également décrits et peuvent être utilisés pour traiter le SIDA, le lupus érythémateux aigu disséminé, les diabètes, la sclérose en plaques et le cancer.
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