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1. WO1996003407 - COMPOUNDS USEFUL AS ANTIPROLIFERATIVE AGENTS AND GARFT INHIBITORS

Publication Number WO/1996/003407
Publication Date 08.02.1996
International Application No. PCT/US1994/008522
International Filing Date 28.07.1994
Chapter 2 Demand Filed 26.02.1996
IPC
C07D 333/38 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
333Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02not condensed with other rings
04not substituted on the ring sulfur atom
26with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 417/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 498/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
498Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 513/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/, C07D477/232
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 517/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
517Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium, or halogen atoms as ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61P 17/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
06Antipsoriatics
C07D 333/38
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
333Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02not condensed with other rings
04not substituted on the ring sulfur
26with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
38Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
C07D 417/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
417Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 513/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
513Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 517/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
517Heterocyclic compounds containing in the condensed system at least one hetero ring having selenium, tellurium or halogen atoms as ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • AGOURON PHARMACEUTICALS, INC. [US/US]; 10350 North Torrey Pines Road La Jolla, CA 92037, US
Inventors
  • VARNEY, Michael, D.; US
  • ROMINES, William, H.; US
  • PALMER, Cynthia, L.; US
Agents
  • TURNER, John, B. ; Finnegan, Henderson, Farabow, Garrett & Dunner 1300 I Street, N.W. Washington, DC 20005-3315, US
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOUNDS USEFUL AS ANTIPROLIFERATIVE AGENTS AND GARFT INHIBITORS
(FR) COMPOSES UTILES COMME AGENTS ANTIPROLIFERATIFS ET INHIBITEURS DE LA GLYCINAMIDE RIBONUCLEOTIDE FORMYLE TRANSFERASE (GARFT)
Abstract
(EN)
The invention relates to compounds, such as compound (1) in equilibrium with its 4-hydroxy tautomer, and its pharmaceutically acceptable salts. Such compounds are useful as inhibitors of glycinamide ribonucleotide formyl transferase (GARFT) or as antiproliferative agents. The invention also pertains to pharmaceutical compositions and methods employing such compounds as GARFT inhibitors or antiproliferative agents. The invention also relates to compounds useful as intermediates for preparing such compounds.
(FR)
L'invention se rapporte à des composés tels que le composé (1) en équilibre avec son 4-hydroxy tautomère, et leurs sels pharmaceutiquement acceptables. Ces composés sont utiles comme inhibiteurs de la glycinamide ribonucléotide formyle transférase (GARFT) ou comme agents antiprolifératifs. L'invention se rapporte également à des compositions pharmaceutiques et à des procédés mettant en oeuvre ces composés utiles comme inhibiteurs de GARFT ou comme agents antiprolifératifs. L'invention se rapporte également à des composés utiles comme intermédiaires dans la préparation de ces composés.
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