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1. WO1996003395 - TAXOIDS, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME

Publication Number WO/1996/003395
Publication Date 08.02.1996
International Application No. PCT/FR1995/000987
International Filing Date 24.07.1995
IPC
C07D 305/14 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
305Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
14condensed with carbocyclic rings or ring systems
C07D 493/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
08Bridged systems
CPC
C07D 305/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
305Heterocyclic compounds containing four-membered rings having one oxygen atoms as the only ring hetero atoms
14condensed with carbocyclic rings or ring systems
C07D 493/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02in which the condensed system contains two hetero rings
08Bridged systems
Applicants
  • RHONE-POULENC RORER S.A. [FR]/[FR] (AllExceptUS)
  • BOUCHARD, Hervé [FR]/[FR] (UsOnly)
  • BOURZAT, Jean-Dominique [FR]/[FR] (UsOnly)
  • COMMERÇON, Alain [FR]/[FR] (UsOnly)
Inventors
  • BOUCHARD, Hervé
  • BOURZAT, Jean-Dominique
  • COMMERÇON, Alain
Agents
  • PILARD, Jacques
Priority Data
94/0920926.07.1994FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) TAXOIDS, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME
(FR) TAXOIDES, LEUR PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT
Abstract
(EN)
Novel taxoids of general formula (I), wherein X is an oxygen or sulphur atom; Z is a hydrogen atom or a radical of general formula (II), wherein R1 is an optionally substituted benzoyl radical or a radical R2-O-CO- where R2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, optionally substituted phenyl or heterocyclyl radical; and R3 is an aromatic alkyl, alkenyl, alkynyl, cycloalkyl, phenyl, naphthyl or heterocyclic radical. The novel products of general formula (I), wherein Z is a radical of general formula (II), have remarkable antitumoral and antineoplastic properties.
(FR)
Nouveaux taxoïdes de formule générale (I) dans laquelle X représente un atome d'oxygène ou de soufre, Z représente un atome d'hydrogène ou un radical de formule générale (II) dans laquelle R1 représente un radical benzoyle éventuellement substitué ou un radical R2-O-CO- dans lequel R2 représente un radical alcoyle, alcényle, alcynyle, cycloalcoyle, cycloalcényle, bicycloalcoyle, phényle éventuellement substitué ou hétérocyclyle, R3 représente un radical alcoyle, alcényle, alcynyle, cycloalcoyle, phényle, naphtyle ou hétérocyclique aromatique. Les nouveaux produits de formule générale (I) dans laquelle Z représente un radical de formule générale (II) présentent des propriétés antitumorales et antileucémiques remarquables.
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