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1. (WO1996003385) 3,4-SUBSTITUTED PYRAZOLES FOR THE TREATMENT OF INFLAMMATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/003385    International Application No.:    PCT/US1995/008788
Publication Date: 08.02.1996 International Filing Date: 20.07.1995
Chapter 2 Demand Filed:    06.02.1996    
IPC:
C07D 231/12 (2006.01)
Applicants: G.D. SEARLE & CO. [US/US]; Corporate Patent Dept., P.O. Box 5110, Chicago, IL 60680-5110 (US) (For All Designated States Except US).
LEE, Len, F. [US/US]; (US) (For US Only).
PENNING, Thomas, D. [US/US]; (US) (For US Only).
KRAMER, Steven, W. [US/US]; (US) (For US Only).
TALLEY, John, J. [US/US]; (US) (For US Only)
Inventors: LEE, Len, F.; (US).
PENNING, Thomas, D.; (US).
KRAMER, Steven, W.; (US).
TALLEY, John, J.; (US)
Agent: BULOCK, Joseph, W.; G.D. Searle & Co., Corporate Patent Dept., P.O. Box 5110, Chicago, IL 60680-5110 (US).
BEIL, Hans, Christian; Postfach 80 01 40, Adelonstrasse 58, D-65901 Frankfurt am Main (DE)
Priority Data:
08/278,297 21.07.1994 US
Title (EN) 3,4-SUBSTITUTED PYRAZOLES FOR THE TREATMENT OF INFLAMMATION
(FR) PYRAZOLES 3,4-SUBSTITUEES DESTINEES AU TRAITEMENT DES INFLAMMATIONS
Abstract: front page image
(EN)A class of pyrazolyl compounds is described for use in treating inflammation and inflammation-related disorders. Compounds of particular interest are defined by formula (II), wherein R?1¿ is selected from alkyl, aralkyl, alkynyl, cyanoalkyl, carboxyalkyl, aminocarbonylalkyl, arylaminocarbonylalkyl, heterocyclicalkyl, and alkoxycarbonylalkyl; wherein R?3¿ is aryl optionally substituted at a substitutable position with one or more radicals independently selected from halo, alkylthio, alkylsulfinyl, alkyl, cyano, carboxyl, alkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, N-alkyl-N-arylaminocarbonyl, haloalkyl, hydroxyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkoxy, amino, alkylamino, arylamino, heterocyclo and nitro; wherein R?4¿ is haloalkyl; and wherein R?5¿ is selected from alkyl and amino; or a pharmaceutically acceptable salt thereof.
(FR)On décrit une classe de composés ou leurs sels pharmacologiquement acceptables, à base de pyrazolyle, utiles pour traiter des inflammations et des troubles en découlant. Les composés présentant un intérêt particulier sont définis par la formule (II), où R?1¿ est choisi parmi alkyle, arakyle, alkynyle, cyanoalkyle, carboxyalkyle, aminocarbonylalkyle, arylaminocarbonylalkyle, alkyle hétérocyclique et alcoxycarbonylalkyle; R?3¿ représente aryle éventuellement substitué en une position substituable avec un ou plusieurs radicaux choisis indépendemment parmi halo, alkylthio, alkylsulfinyle, alkyle, cyano, carboxyle, alcoxycarbonyle, aminocarbonyle, alkylaminocarbonyle, arylaminocarbonyle, N-alkyle-N-arylamonicarbonyle, haloalkyle, hydroxyle, alcoxy, hydroxyalkyle, alcoxyalkyle, haloalcoxy, amino, alkylamino, arylamino, hétérocyclo et nitro; R?4¿ représente haloalkyle, et R?5¿ est choisi entre alkyle et amino.
Designated States: AM, AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LT, LU, LV, MD, MG, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (KE, MW, SD, SZ, UG)
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)