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1. WO1996003382 - MONOMERIC AND DIMERIC NAPHTHYLISOQUINOLINE ALKALOIDS AND SYNTHESIS METHODS THEREOF

Publication Number WO/1996/003382
Publication Date 08.02.1996
International Application No. PCT/US1995/009132
International Filing Date 19.07.1995
Chapter 2 Demand Filed 19.02.1996
IPC
C07D 217/02 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
02with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
C07D 217/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
02with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
04with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
CPC
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
C07D 217/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
02with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
C07D 217/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
217Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
02with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
04with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
Applicants
  • THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health Office of Technology Transfer Box OTT Bethesda, MD 20892-9902, US
Inventors
  • BRINGMANN, Gerhard; DE
  • HARMSEN, Sven; DE
  • GOTZ, Roland; DE
  • BOYD, Michael, R.; US
Agents
  • KILYK, John, Jr. ; Leydig, Voit & Mayer, Ltd. Suite 4900 Two Prudential Plaza 180 North Stetson Chicago, IL 60601-6780, US
Priority Data
279,29122.07.1994US
279,33922.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MONOMERIC AND DIMERIC NAPHTHYLISOQUINOLINE ALKALOIDS AND SYNTHESIS METHODS THEREOF
(FR) ALCALOIDES MONOMERE ET DIMERE DE NAPHTHYLISOQUINOLEINE ET PROCEDES SERVANT A REALISER LEUR SYNTHESE
Abstract
(EN)
The present invention provides methods of preparing monomeric naphthylisoquinoline alkaloids, including the antiparasitic korupensamines and related compounds, as well as non-korupensamines and other monomeric naphthylisoquinoline alkaloids. The present invention also provides methods of preparing dimeric naphthylisoquinoline alkaloids by coupling together two monomeric naphthylisoquinoline alkaloids, each of which may be the same or different, and one, both, or neither of which may possess a C-8' to C-5 naphthalene/isoquinoline linkage, to form homodimers or heterodimers, including the antiviral michellamines. The present invention further provides new, medically useful monomeric naphthylisoquinoline compounds and homodimeric and heterodimeric naphthylisoquinoline compounds and derivatives thereof.
(FR)
L'invention concerne des procédés de préparation d'alcaloïdes monomère de naphthylisoquinoléine, dont les korupensamines antiparasitaires et des composés apparentés, ainsi que de produits autres que des korupensamines et d'autres alcaloïdes monomère de naphthylisoquinoléine. Elle concerne également des procédés de préparation d'alcaloïdes dimère de naphthylisoquinoléine par couplage de deux alcaloïdes monomère de naphthylisoquinoléine, dont chacun peut être semblable ou différent et dont l'un, les deux ou aucun des deux peut posséder une liaison C-8' à C-5 naphtalène/isoquinoléine, pour former des homodimères ou des hétérodimères, dont les michellamines antivirales. Elle concerne, de plus, de nouveaux composés monomères de naphthylisoquinoléine, ainsi que de nouveaux composés homodimères et hétérodimères de naphthylisoquinoléine et leurs dérivés médicalement efficaces.
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