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Machine translation
1. (WO1996003381) DIMERIC ARYLISOQUINOLINE ALKALOIDS AND SYNTHESIS METHODS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/003381    International Application No.:    PCT/US1995/009070
Publication Date: 08.02.1996 International Filing Date: 19.07.1995
Chapter 2 Demand Filed:    19.02.1996    
IPC:
C07D 217/02 (2006.01), C07D 217/04 (2006.01)
Applicants: THE UNITED STATES OF AMERICA, represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health, Office of Technology Transfer, Box OTT, Bethesda, MD 20892-9902 (US).
THE TRUSTEES OF BOSTON COLLEGE [US/US]; 140 Commonwealth Avenue, Chestnut Hill, MA 02167 (US)
Inventors: BRINGMANN, Gerhard; (DE).
BOYD, Michael, R.; (US).
GOTZ, Roland; (DE).
KELLY, T., Ross; (US)
Agent: KILYK, John, Jr.; Leydig, Voit & Mayer, Ltd., Suite 4900, Two Prudential Plaza, 180 North Stetson, Chicago, IL 60601-6780 (US)
Priority Data:
279,339 22.07.1994 US
279,291 22.07.1994 US
305,211 13.09.1994 US
363,684 23.12.1994 US
Title (EN) DIMERIC ARYLISOQUINOLINE ALKALOIDS AND SYNTHESIS METHODS THEREOF
(FR) ALCALOIDES DU TYPE ARYLISOQUINOLEINES DIMERES ET PROCEDES POUR LES SYNTHETISER
Abstract: front page image
(EN)The present invention provides a method of preparing dimeric arylisoquinoline alkaloids by coupling two isoquinoline building blocks, each of which may be the same or different, together with a symmetrical or nonsymmetrical biaryl building block to form homodimers or heterodimers, including the antiviral michellamines. The present invention also provides new, medically useful homodimeric and heterodimeric arylisoquinoline compounds and derivatives thereof.
(FR)La présente invention concerne un procédé pour préparer des alcaloïdes du type arylisoquinoléines dimères en couplant deux unités constitutives d'isoquinoléine, qui peuvent être identiques ou différentes, avec une unité constitutive du type biaryle symétrique ou non symétrique, pour former des homodimères ou des hétérodimères, en particulier des michellamines antivirales. La présente invention concerne également de nouveaux composés qui sont des arylisoquinoléines homodimères et hétérodimères et leurs dérivés, et qui sont utiles en médecine.
Designated States: AM, AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LT, LU, LV, MD, MG, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TT, UA, UG, UZ, VN.
African Regional Intellectual Property Organization (KE, MW, SD, SZ, UG)
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)