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1. WO1996003374 - THROMBIN INHIBITORS

Publication Number WO/1996/003374
Publication Date 08.02.1996
International Application No. PCT/US1995/009007
International Filing Date 18.07.1995
Chapter 2 Demand Filed 09.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 5/062 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
062the side chain of the first amino acid being acyclic, e.g. Gly, Ala
C07K 5/065 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides having up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
065the side chain of the first amino acid containing carbocyclic rings, e.g. Phe, Tyr
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 7/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
7Drugs for disorders of the blood or the extracellular fluid
02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
C07K 5/06026
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06008with the first amino acid being neutral
06017and aliphatic
06026the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
C07K 5/0606
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06008with the first amino acid being neutral
06017and aliphatic
0606the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
C07K 5/06078
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
5Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
04containing only normal peptide links
06Dipeptides
06008with the first amino acid being neutral
06078and aromatic or cycloaliphatic
Applicants
  • MERCK & CO., INC. [US]/[US] (AllExceptUS)
  • LUMMA, William, C. [US]/[US] (UsOnly)
  • FREIDINGER, Roger, M. [US]/[US] (UsOnly)
  • BRADY, Stephen, F. [US]/[US] (UsOnly)
  • SANDERSON, Philip, E. [GB]/[US] (UsOnly)
  • FENG, Dong-Mei [CN]/[US] (UsOnly)
  • LYLE, Terry, Alan [US]/[US] (UsOnly)
  • STAUFFER, Kenneth, James [US]/[US] (UsOnly)
  • TUCKER, Thomas, Joseph [US]/[US] (UsOnly)
  • VACCA, Joseph, P. [US]/[US] (UsOnly)
Inventors
  • LUMMA, William, C.
  • FREIDINGER, Roger, M.
  • BRADY, Stephen, F.
  • SANDERSON, Philip, E.
  • FENG, Dong-Mei
  • LYLE, Terry, Alan
  • STAUFFER, Kenneth, James
  • TUCKER, Thomas, Joseph
  • VACCA, Joseph, P.
Common Representative
  • MERCK & CO., INC.
Priority Data
279,46022.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THROMBIN INHIBITORS
(FR) INHIBITEURS DE LA THROMBINE
Abstract
(EN)
Compounds of the invention have structure (I) for example formula (II). These compounds inhibit thrombin and associated thrombosis.
(FR)
Les composés de l'invention ont la structure représentée par la formule (I), par exemple la formule (II). Ces composés inhibent la thrombine et empêchent les thromboses associées.
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