WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO1996003364) BENZOYLETHYLENE DERIVATIVE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/003364    International Application No.:    PCT/JP1995/001475
Publication Date: 08.02.1996 International Filing Date: 25.07.1995
IPC:
C07C 59/90 (2006.01), C07C 69/738 (2006.01), C07C 225/16 (2006.01), C07C 225/20 (2006.01), C07C 229/44 (2006.01), C07C 235/78 (2006.01), C07C 255/40 (2006.01), C07C 255/41 (2006.01), C07C 255/42 (2006.01), C07C 255/43 (2006.01), C07C 255/56 (2006.01), C07C 317/28 (2006.01), C07C 323/29 (2006.01), C07C 323/62 (2006.01), C07D 295/084 (2006.01), C07D 295/104 (2006.01), C07D 295/125 (2006.01), C07D 295/135 (2006.01), C07D 295/145 (2006.01), C07D 333/34 (2006.01)
Applicants: MITSUBISHI CHEMICAL CORPORATION [JP/JP]; 5-2, Marunouchi 2-chome, Chiyoda-ku, Tokyo 100 (JP) (For All Designated States Except US).
KITANO, Yasunori [JP/JP]; (JP) (For US Only).
INOKAWA, Haruki [JP/JP]; (JP) (For US Only).
TAKAYANAGI, Hisao [JP/JP]; (JP) (For US Only).
YANO, Tamaki [JP/JP]; (JP) (For US Only).
UMEKI, Hiroe [JP/JP]; (JP) (For US Only).
HARA, Hiroto [JP/JP]; (JP) (For US Only)
Inventors: KITANO, Yasunori; (JP).
INOKAWA, Haruki; (JP).
TAKAYANAGI, Hisao; (JP).
YANO, Tamaki; (JP).
UMEKI, Hiroe; (JP).
HARA, Hiroto; (JP)
Agent: HASEGAWA, Koji; Mitsubishi Chemical Corporation, 5-2, Marunouchi 2-chome, Chiyoda-ku, Tokyo 100 (JP)
Priority Data:
6/175357 27.07.1994 JP
Title (EN) BENZOYLETHYLENE DERIVATIVE
(FR) DERIVE DU BENZOYLETHYLENE
Abstract: front page image
(EN)A benzoylethylene derivative represented by general formula (I) and a salt thereof wherein R?1¿ to R?5¿ represent each hydrogen, -OR?9¿ (R?9¿ being hydrogen, C¿1?-C¿5? alkyl, etc.), etc.; R?6¿ represents hydrogen, C¿1?-C¿5? alkyl, etc.; R?7¿ represents hydrogen, cyano, C¿1?-C¿5? alkyl, -SO¿q?R?15¿ (q being 0, 1 or 2, and R?15¿ being thienyl, phenyl, etc.), etc.; and R?8¿ represents cyano, -CR?22¿R?23¿X (R?22¿ and R?23¿ being each hydrogen, C¿1?-C¿5? alkyl, etc., and X being -NR?24¿R?25¿ (wherein R?24¿ and R?25¿ represent each C¿1?-C¿5? alkyl, or R?24¿ and R?25¿ are combined together to represent alkylene, etc.)), etc. The derivative has potent activities of tyrosine kinase inhibition and cancer cell growth inhibition and is useful as a carcinostatic agent.
(FR)Dérivé du benzoyléthylène, et ses sels, de formule générale (1) dans laquelle R?1¿ à R?5¿ représentent chacun hydrogène, -OR?9¿ (R?9¿ représentant hydrogène, C¿1?-C¿5? alkyle, etc.) etc.; R?6¿ représente hydrogène, C¿1?-C¿5? alkyle; R?7¿ représente hydrogène, cyano, C¿1?-C¿5? alkyle, -SO¿q?R?15¿ (q valant 0, 1, ou 2 et R?15¿ équivalant à thyényle, phényle etc.), etc.; R?8¿ représente, cyano, -CR?22¿R?23¿ (R?22¿ et R?23¿ représentant chacun hydrogène, C¿1?-C¿5? alkyle etc., et X représentant -NR?24¿R?25¿ (R?24¿ et R?25¿ équivalant chacun à C¿1?-C¿5? alkyle, ou R?24¿ et R?25¿ étant combinés ensemble pour représenter alkylène, etc.)), etc. Ce dérivé présente des activités puissantes d'inhibition de la tyrosine kinase et de la croissance des cellules cancéreuses, et s'avère utile comme agent cancérostatique.
Designated States: CA, JP, US.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)