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1. WO1996003205 - PREPARATION OF CELLS OR DISPERSED ACTIVE SUBSTANCES INTO MICRO-ENCAPSULATED FORM AND THUS OBTAINED MICRO-CAPSULES

Publication Number WO/1996/003205
Publication Date 08.02.1996
International Application No. PCT/DE1995/000972
International Filing Date 25.07.1995
Chapter 2 Demand Filed 18.01.1996
IPC
A61K 9/50 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
B01J 13/04 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
13Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
02Making microcapsules or microballoons
04by physical processes, e.g. drying, spraying
CPC
A61K 9/5036
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5005Wall or coating material
5021Organic macromolecular compounds
5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
A61K 9/5089
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5089Processes
B01J 13/043
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
13Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
02Making microcapsules or microballoons
04by physical processes, e.g. drying, spraying
043Drying and spraying
Applicants
  • ZIMMERMANN, Ulrich [DE]/[DE]
Inventors
  • ZIMMERMANN, Ulrich
Agents
  • PÖHNER, Wilfried
Priority Data
P 44 26 396.126.07.1994DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) HERSTELLUNG VON ZELLEN ODER DISPERGIERTEN WIRKSTOFFEN IN MIKROVERKAPSELTER FORM SOWIE DERART HERGESTELLTE MIKROKAPSEL
(EN) PREPARATION OF CELLS OR DISPERSED ACTIVE SUBSTANCES INTO MICRO-ENCAPSULATED FORM AND THUS OBTAINED MICRO-CAPSULES
(FR) PREPARATION DE CELLULES OU DE PRINCIPES ACTIFS DISPERSES SOUS FORME DE MICROCAPSULES, ET MICROCAPSULES AINSI OBTENUES
Abstract
(DE)
Vorgeschlagen wird die Herstellung von Zellen oder dispergierten Wirkstoffen in mikroverkapselter Form hoher Konzentration, bei der nach verschiedenen Verfahren eine aus Hülle und dem die Zellen oder dispergierten Wirkstoffe aufnehmenden Kern aufgebaute Mikrokapsel hergestellt wird, bei denen das Verfahrensparameter so eingestellt ist, daß das Volumen der Tropfen das 1,5-4fache des Kernvolumens beträgt und anschließend einer Dichtezentrifuge zur Trennung zugeführt wird, deren Dichtegradient so eingestellt ist, daß die Dichte des eingesetzten Mediums höher als das der Hülle, jedoch niedriger als die Dichte der Hülle mit Kern gewählt ist.
(EN)
The preparation of cells or dispersed active substances into high-concentration micro-capsules is disclosed. Micro-capsules having a shell and a core for receiving the cells or dispersed active substances are prepared by various processes, and the process parameters are set so that the droplet volume be 1.5 to 4 times the core volume. The micro-capsules are then supplied to a density centrifugal separator with a density gradient adjusted so that the density of the used medium is higher than that of empty micro-capsule shells but lower than the density of core-containing shells.
(FR)
L'invention concerne la préparation de cellules ou de principes actifs dispersés sous forme de microcapsules à haute concentration. On produit par divers procédés des microcapsules constituées d'une enveloppe et d'un noyau destiné à loger des cellules ou des principes actifs dispersés. On ajuste les paramètres de mise en oeuvre du procédé de sorte que le volume des gouttelettes soit de 1,5 à 4 fois le volume du noyau. Les microcapsules sont ensuite amenées à un centrifugeuse de séparation en fonction de la densité, dont le gradient de densité est ajusté de sorte que la densité du milieu utilisé soit supérieure à celle des enveloppes vides mais inférieure à la densité des enveloppes pourvues de noyaux.
Also published as
Latest bibliographic data on file with the International Bureau