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1. WO1996003160 - FIBRIN-CELL SUSPENSION FOR CONSTRUCTION OF NEW TISSUE

Publication Number WO/1996/003160
Publication Date 08.02.1996
International Application No. PCT/US1995/009374
International Filing Date 26.07.1995
IPC
A61L 24/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
A61L 26/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
26Chemical aspects of, or use of materials for, liquid bandages
A61L 27/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
38Animal cells
C12N 5/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
CPC
A61L 24/0005
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
24Surgical adhesives or cements; Adhesives for colostomy devices
0005Ingredients of undetermined constitution or reaction products thereof
A61L 26/0042
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
26Chemical aspects of, or use of materials for, ; wound dressings or; bandages ; in liquid, gel or powder form
0009containing macromolecular materials
0028Polypeptides; Proteins; Degradation products thereof
0042Fibrin; Fibrinogen
A61L 26/0057
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
26Chemical aspects of, or use of materials for, ; wound dressings or; bandages ; in liquid, gel or powder form
0057Ingredients of undetermined constitution or reaction products thereof
A61L 27/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
38containing added animal cells
A61L 27/3804
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
38containing added animal cells
3804characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
A61L 27/3839
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
38containing added animal cells
3839characterised by the site of application in the body
Applicants
  • CHILDREN'S MEDICAL CENTER CORPORATION [US/US]; 55 Shattuck Street Boston, MA 02115, US
  • THE GENERAL HOSPITAL CORPORATION [US/US]; 55 Fruit Street Boston, MA 02114, US
Inventors
  • VACANTI, Charles, A.; US
  • RANDOLPH, Mark, A.; US
  • SIMS, C., Derek; US
  • BUTLER, Peter, E., M.; US
Agents
  • PABST, Patrea, L.; Arnall Golden & Gregory 2800 One Atlantic Center 1201 West Peachtree Street Atlanta, GA 30309-3450, US
Priority Data
280,31226.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) FIBRIN-CELL SUSPENSION FOR CONSTRUCTION OF NEW TISSUE
(FR) SUSPENSION DE CELLULES DE FIBRINE POUR LA CREATION DE NOUVEAUX TISSUS
Abstract
(EN)
A method for creating new tissue is described wherein cells are suspended in cryoprecipitate or fibrinogen (jointly referred to herein as 'fibrinogen') which is clotted by exposure to thrombin or other serine esterase. In the preferred embodiment, the cells and fibrinogen are autologous, derived by biopsy and cryoprecipitation of a plasma sample, respectively. The method is particularly useful for creation of new cartilage in the repair of defects such as worn or torn joint linings or construction of ears and noses. The method is also particularly useful where tissue such as endothelial tissue or cartilage is used to oblate a structure, such as fallopian tubes or the vas deferens, or in the repair of defects such as incomplete closure of structures, for example, the heart. Examples demonstrate formation of new cartilage in mice.
(FR)
Procédé de création de nouveaux tissus dans lequel des cellules sont mises en suspension dans un cryoprécipité ou dans du fibrinogène (tous deux désignés ici par fibrinogène) qui est coagulé en présence de thrombine ou d'une autre sérine estérase. Dans le mode de réalisation préféré, les cellules et le fibrinogène sont autologues, et dérivés respectivement par biopsie et cryoprécipitation d'un échantillon de plasma. Ce procédé s'avère particulièrement utile pour créer de nouveaux cartilages dans la réparation de défectuosités telles que des ligaments usés ou déchirés, ou la reconstitution de nez ou d'oreilles. Il est particulièrement utile lorsque des tissus tels que des cartilages ou de l'endothélium sont utilisés pour obturer une structure telle que les trompes de Fallope ou le canal déférent, ou pour réparer des malformations telles que la fermeture incomplète de structures, telles que le c÷ur. Des exemples décrivent la formation de nouveaux cartilages chez les souris.
Also published as
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