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1. WO1996003133 - NOVEL ANTI-HIV DRUG

Publication Number WO/1996/003133
Publication Date 08.02.1996
International Application No. PCT/JP1995/001456
International Filing Date 21.07.1995
IPC
C07H 21/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
CPC
A61K 31/7105
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7105Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
A61K 31/7125
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
7125Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Applicants
  • KAJI, Akira [JP]/[JP]
  • KAJI, Hideko [JP]/[JP]
Inventors
  • KAJI, Akira
  • KAJI, Hideko
Agents
  • KAWAKAMI, Norio
Priority Data
6/20002922.07.1994JP
6/20003022.07.1994JP
6/20003122.07.1994JP
6/20003222.07.1994JP
6/23831326.08.1994JP
6/23831426.08.1994JP
6/23831526.08.1994JP
6/23831626.08.1994JP
6/23831726.08.1994JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) NOVEL ANTI-HIV DRUG
(FR) NOUVEAU MEDICAMENT ANTI VIH
Abstract
(EN)
An anti-HIV drug containing an active ingredient comprising at least one member selected from among dito octabase phosphodiester-linked and phosphorothioester-linked oligoribonucleotides represented by the tetrabase homologues represented by the following formulae: (III) GpGpGpGp, (VII) pGpGpGpG, (XI) GsGsGsGp, (XVII) pGsGsGsG, (XXI) GsGsGsG, wherein G represents a guanosine structure; p represents a phosphate residue forming an ester linkage with an adjacent G; and s represents a phosphorothiophosphate residue forming a phosphorothioester linkage with an adjacent G.
(FR)
Médicament anti VIH contenant un principe actif comprenant au moins un constituant sélectionné à partir d'oligoribonucléotides à liaisons phosphodiester et phosphorothioester de di- à octabase, représentés par les homologues à tétrabase représentés par les formules suivantes (III), (VII), (XI), (XVII) et (XXI). G p G p G p G p (III), p G p G p G p G (VII), G s G s G s G p (XI), p G s G s G s G (XVII), G s G s G s G (XXI), dans lesquelles G représente une structure guanosine, p représente un résidu de phosphate constituant une liaison ester comportant un G contigu et s représente un résidu de phosphorothiophosphate constituant une liaison phosphorothioester comportant un G contigu.
Also published as
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