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1. WO1996003127 - A METHOD OF TREATING CHEMICAL DEPENDENCY IN MAMMALS AND A COMPOSITION THEREFOR

Publication Number WO/1996/003127
Publication Date 08.02.1996
International Application No. PCT/US1995/009136
International Filing Date 25.07.1995
Chapter 2 Demand Filed 12.02.1996
IPC
A61K 31/55 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
C07D 487/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
22in which the condensed system contains four or more hetero rings
CPC
A61K 31/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
55having seven-membered rings, e.g. azelastine, pentylenetetrazole
C07D 487/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
22in which the condensed system contains four or more hetero rings
Applicants
  • NDA INTERNATIONAL, INC. [US/US]; 46 Oxford Place Staten Island, NY 10301, US
Inventors
  • MASH, Deborah, C.; US
  • SANCHEZ-RAMOS, Juan; US
  • HEARN, W., Lee; US
Priority Data
280,18725.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) A METHOD OF TREATING CHEMICAL DEPENDENCY IN MAMMALS AND A COMPOSITION THEREFOR
(FR) PROCEDE ET COMPOSITION DE TRAITEMENT DE LA DEPENDANCE CHIMIQUE CHEZ LES MAMMIFERES
Abstract
(EN)
An essentially pure noribogaine compound having formula (I) wherein R is hydrogen or a hydrolyzable group of formula (II) wherein X is an unsubstituted C1-C12 group or a C1-C12 group substituted by lower alkyl or lower alkoxy groups, wherein the noribogaine compound having the hydrolyzable group hydrolyzes $i(in vivo) to form 12-hydroxy ibogamine.
(FR)
Composé essentiellement pur de noribogaïne possédant la formule (I), dans laquelle R représente hydrogène ou un groupe hydrolysable possédant la formule (II), dans laquelle X représente un groupe C1-C12 insubstitué ou un groupe C1-C12 substitué par des groupes alkyle inférieur ou alcoxy inférieur, le composé de noribogaïne possédant le groupe hydrolysable s'hydrolysant $i(in vivo), afin de produire 12-hydroxy ibogamine.
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