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1. WO1996003122 - USE OF GABAPENTIN IN THE TREATMENT OF ANXIETY AND PANIC

Publication Number WO/1996/003122
Publication Date 08.02.1996
International Application No. PCT/US1995/008702
International Filing Date 11.07.1995
Chapter 2 Demand Filed 10.02.1996
IPC
A61K 31/197 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A61K 31/197
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
Applicants
  • WARNER-LAMBERT COMPANY [US/US]; 201 Tabor Road Morris Plains, NJ 07950, US
Inventors
  • WOODRUFF, Geoffrey, Neil; GB
  • GEE, Nicolas, S.; GB
  • SINGH, Lakhbir; GB
  • BROWN, Jason, P.; GB
Agents
  • RYAN, M., Andrea; Warner-Lambert Company 201 Tabor Road Morris Plains, NJ 07950 , US
  • MANSMANN, Ivo ; Warner-Lambert Company Legal Division, Patent Dept. Gödecke AG Mooswaldallee 1 D-79090 Freiburg, DE
Priority Data
08/281,28527.07.1994US
08/445,39806.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) USE OF GABAPENTIN IN THE TREATMENT OF ANXIETY AND PANIC
(FR) UTILISATION DE LA GABAPENTINE DANS LE TRAITEMENT DE L'ANXIETE ET DE LA PANIQUE
Abstract
(EN)
The instant invention is novel uses of known cyclic amino acids. Such compounds as gabapentin are useful in the treatment of anxiety and in the treatment and/or prevention of panic attacks. The partial N-terminal sequence of the gabapentin binding protein has been determined to be identical to the N-terminal sequence of the mature $g(a)2$g(d) subunit of the L-type Ca2+ channel from rabbit skeletal muscle.
(FR)
La présente invention concerne des utilisations nouvelles d'amino-acides cycliques connus. Des composés tels que la gabapentine sont utiles dans le traitement de l'anxiété et dans le traitement et/ou la prévention des accès de panique. Il a été déterminé que la séquence partielle N-terminale de la protéine de liaison de la gabapentine est identique à la séquence N-terminale de la sous-unité $g(a)2$g(d) mature du canal calcique de type L des muscles squelettiques du lapin.
Also published as
CZPV1997-162
NZ290050
RO97-00128
SK199700090
SK9097
Latest bibliographic data on file with the International Bureau