Processing

Please wait...

Settings

Settings

1. WO1996003093 - BIOPROSTHETIC IMPLANTS AND METHOD OF MAKING AND USING SAME

Publication Number WO/1996/003093
Publication Date 08.02.1996
International Application No. PCT/US1995/009590
International Filing Date 27.07.1995
Chapter 2 Demand Filed 28.02.1996
IPC
A61L 27/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
A61L 27/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
38Animal cells
CPC
A61L 27/3633
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
3604characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
3633Extracellular matrix [ECM]
A61L 27/3687
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
3683subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
3687characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
A61L 27/3804
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
38containing added animal cells
3804characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
Applicants
  • VESELY, Ivan [CA/US]; US
  • NOSEWORTHY, Ronald [CA/CA]; CA
  • PRINGLE, Gordon [CA/CA]; CA
Inventors
  • VESELY, Ivan; US
  • NOSEWORTHY, Ronald; CA
  • PRINGLE, Gordon; CA
Agents
  • CORSO, Joseph, J. ; Pearne, Gordon, McCoy & Granger 1200 Leader Building Cleveland, OH 44114, US
Priority Data
08/282,05928.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BIOPROSTHETIC IMPLANTS AND METHOD OF MAKING AND USING SAME
(FR) IMPLANTS BIOPROTHETIQUES ET LEUR PROCEDE DE FABRICATION ET D'UTILISATION
Abstract
(EN)
The invention provides bioprosthetic implants from which the lipids have been removed by treatment with enzymes which degrade lipids, and methods of making and using the same. The enzymes include lipases and phospholipases. The removal of lipids from the bioprosthetic implants according to the present invention decreases the calcification of the bioprosthesis. The bioprosthetic implants preferably may be recellularized with fibroblasts or myofibroblasts before implanting the bioprosthesis in the body of a person.
(FR)
L'invention concerne des implants bioprothétiques dont les lipides ont été éliminés par traitement par des enzymes dégradant les lipides. L'invention a également pour objet des procédés de production et d'utilisation de ces implants. Ces enzymes comprennent des lipases et des phospholipases. L'élimination des lipides de ces implants selon la présente invention réduit la calcification de la bioprothèse. Ces implants bioprothétiques peuvent, de préférence, être recellularisés par des fibroblastes ou des myofibroblastes avant leur implantation dans le corps d'un patient.
Latest bibliographic data on file with the International Bureau