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1. WO1996003051 - PRODUCTION OF COLLAGEN IN THE MILK OF TRANSGENIC MAMMALS

Publication Number WO/1996/003051
Publication Date 08.02.1996
International Application No. PCT/US1995/009580
International Filing Date 27.07.1995
Chapter 2 Demand Filed 04.01.1996
IPC
A23C 9/20 2006.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
CDAIRY PRODUCTS, e.g. MILK, BUTTER, CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
9Milk preparations; Milk powder or milk powder preparations
20Dietetic milk products not covered by groups A23C9/12-A23C9/1897
A23J 1/20 2006.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
JPROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
1Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
20from milk, e.g. casein; from whey
A23J 3/06 2006.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
JPROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
3Working-up of proteins for foodstuffs
04Animal proteins
06Gelatine
C07K 14/78 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
C12N 15/85 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
CPC
A01K 2207/15
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2207Modified animals
15Humanized animals
A01K 2217/00
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
A01K 2217/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
A01K 2227/10
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
A01K 2227/101
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
101Bovine
A01K 2227/105
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
105Murine
Applicants
  • GENE PHARMING EUROPE B.V. [NL/NL]; Niels Bohrweg 11-13 NL-2333 CA Leiden, NL (AllExceptUS)
  • COLLAGEN CORPORATION [US/US]; 2500 Faber Place Palo Alto, CA 94303, US (AllExceptUS)
  • KARATZAS, Costas, N. [GR/CA]; CA (UsOnly)
  • PIEPER, Frank [NL/NL]; NL (UsOnly)
  • DE WIT, Ineke [NL/NL]; NL (UsOnly)
  • PLATENBURG, Gerard [NL/NL]; NL (UsOnly)
  • BERG, Richard, A. [US/US]; US (UsOnly)
  • TOMAN, Paul, David [US/US]; US (UsOnly)
Inventors
  • KARATZAS, Costas, N.; CA
  • PIEPER, Frank; NL
  • DE WIT, Ineke; NL
  • PLATENBURG, Gerard; NL
  • BERG, Richard, A.; US
  • TOMAN, Paul, David; US
Agents
  • LIEBESCHUETZ, Joe ; Townsend and Townsend and Crew One Market Plaza 20th floor Steuart Street Tower San Francisco, CA 94105, US
Priority Data
08/281,49327.07.1994US
08/482,17307.06.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PRODUCTION OF COLLAGEN IN THE MILK OF TRANSGENIC MAMMALS
(FR) PRODUCTION DE COLLAGENE DANS LE LAIT DE MAMMIFERES TRANSGENIQUES
Abstract
(EN)
The invention provides transgenic nonhuman mammals capable secreting exogenous procollagen or collagen into their milk. The mammals are healthy and capable of producing procollagen or collagen at high levels, usually in trimeric form. Suitable transgenes for incorporation into the mammals are also provided.
(FR)
La présente invention concerne des mammifères transgéniques non humains sécrétant du procollagène exogène ou du collagène exogène dans leur lait. Ces mammifères sont en bonne santé et capables de produire des niveaux élevés de procollagène ou de collagène, habituellement sous forme trimère. L'invention concerne également des transgènes destinés à être administrés aux mammifères.
Also published as
KR1019970700600
NZ291042
Latest bibliographic data on file with the International Bureau