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1. WO1996003043 - HUMAN BRAIN SPECIFIC KINASE

Publication Number WO/1996/003043
Publication Date 08.02.1996
International Application No. PCT/US1995/009334
International Filing Date 26.07.1995
Chapter 2 Demand Filed 23.02.1996
IPC
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/705 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/705
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
C12N 2799/022
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2799Uses of viruses
02as vector
021for the expression of a heterologous nucleic acid
022where the vector is derived from an adenovirus
Applicants
  • RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY [US]/[US]
Inventors
  • ZHOU, Renping
  • PAULHIAC, Clara
Agents
  • GOLDSTEIN, Jorge, A.
Priority Data
08/279,85526.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HUMAN BRAIN SPECIFIC KINASE
(FR) KINASE SPECIFIQUE DU CERVEAU HUMAIN
Abstract
(EN)
The present invention relates, in general, to human brain specific kinase, hBsk. In particular, the present invention relates to nucleic acid molecules coding for hBsk; hBsk polypeptides; recombinant nucleic acid molecules; cells containing the recombinant nucleic acid molecules; antibodies having binding affinity specifically to hBsk; hybridomas containing the antibodies; nucleic acid probes for the detection of hBsk nucleic acid; a method of detecting hBsk nucleic acid or polypeptide in a sample; and kits containing nucleic acid probes or antibodies. This invention further relates to bioassays using the nucleic acid sequence, receptor protein or antibodies of this invention to diagnose, assess, or prognose a mammal afflicted with neurodegenerative disease. Therapeutic uses for the hBsk receptor-like tyrosine kinase are also provided. This invention also relates to the ligand for the hBsk receptor, and diagnostic and therapeutic uses for the hBsk ligand.
(FR)
L'invention porte sur une kinase, la hBSK, spécifique du cerveau humain et en particulier sur des molécules d'acide nucléique codant pour la hBsk, des polypeptides de la hBsk, sur des molécules d'acide nucléique de recombinaison, des cellules contenant lesdites molécules d'acide nucléique de recombinaison, des anticorps présentant une affinité de liaison spécifique vis-à-vis de la hBsk, des hybridomes contenant lesdits anticorps, des sondes d'acide nucléique de détection de l'acide nucléique de la hBsk, une méthode de détection de l'acide nucléique ou du polypeptide de la hBsk, des matériels contenant lesdites sondes d'acide nucléique et lesdits anticorps. L'invention porte en outre sur des dosages biologiques utilisant la séquence de l'acide nucléique, la protéine réceptrice ou les anticorps objets de cette invention pour diagnostiquer, évaluer ou pronostiquer une maladie neurodégénérative chez un mammifère. Sont également inclus les utilisations thérapeutiques de la tyrosine kinase de type récepteur de la hBsk et le ligand du récepteur de la hBSK ainsi que ses utilisations thérapeutiques.
Also published as
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