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1. WO1996002837 - APPARATUS AND METHOD FOR THE DETECTION AND ASSAY OF ORGANIC MOLECULES

Publication Number WO/1996/002837
Publication Date 01.02.1996
International Application No. PCT/US1995/009197
International Filing Date 19.07.1995
Chapter 2 Demand Filed 14.02.1996
IPC
B01J 19/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
G01N 33/543 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
CPC
B01J 19/004
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
19Chemical, physical or physico-chemical processes in general; Their relevant apparatus
0006Controlling or regulating processes
004Multifunctional apparatus for automatic manufacturing of various chemical products
G01N 33/54373
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
54366Apparatus specially adapted for solid-phase testing
54373involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
Y10S 436/807
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
436Chemistry: analytical and immunological testing
807Apparatus included in process claim, e.g. physical support structures
Applicants
  • SIOS, INC. [US/US]; 965 Farmington Road Macedon, NY 14502, US
Inventors
  • FORSYTH, James, M.; US
  • FRANKEL, Robert, D.; US
Agents
  • JASON, Edward, C. ; Harris Beach & Wilcox, L.L.P. 300 S. State Street One Park Place- 4th Floor Syracuse, NY 13202, US
  • WALL, Thomas, J.; Harris Beach & Wilcox, LLP 300 S. State Street One Park Place 4th Floor Syracuse, NY 13202, US
Priority Data
08/278,03320.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) APPARATUS AND METHOD FOR THE DETECTION AND ASSAY OF ORGANIC MOLECULES
(FR) APPAREIL ET PROCEDE POUR LA DETECTION ET LE DOSAGE DE MOLECULES ORGANIQUES
Abstract
(EN)
A system for biomolecular separation and detection of a molecular species includes a solid state laser detector having a sample channel therein. The presence of a molecular species is indicated by a frequency shift in the laser's output, which is detected by optical heterodyning the laser's output with the output of a reference laser. The interior of the sample channel is optionally coated with a ligand for binding the molecular species of interest. The system involves preprocessing a sample by electroosmotic separation in channels that are lithographically formed in a two-dimensional planar substrate. Molecular separation is also accomplished in a nanostructural molecular sieve comprising spaced apart posts defining narrow channels therebetween.
(FR)
Cette invention se rapporte à un système qui, par voie biomoléculaire, sépare et détecte une espèce moléculaire et qui utilise à cet effet un détecteur à laser à solides contenant un canal porte-échantillon. La présence d'une espèce moléculaire est indiquée par un décalage de fréquence dans la sortie du laser, ce décalage étant détecté par traitement optique hétérodyne de la sortie dudit laser avec la sortie d'un laser de référence. L'intérieur du canal porte-échantillon est éventuellement tapissé d'un ligand qui sert à fixer l'espèce moléculaire en question. Dans ledit système, on traite préalablement un échantillon par séparation électro-osmotique dans des canaux qui sont formés par voie lithographique dans un substrat plan bidimensionnel. La séparation moléculaire s'effectue également dans un tamis moléculaire nanostructurel comportant des segments droits espacés définissant entre-eux des canaux étroits.
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