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1. (WO1996002830) BIOSENSOR AND METHOD AND INSTRUMENT FOR DEPOSITION OF ALTERNATING MONOMOLECULAR LAYERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/002830    International Application No.:    PCT/IB1995/000588
Publication Date: 01.02.1996 International Filing Date: 14.07.1995
Chapter 2 Demand Filed:    14.02.1996    
IPC:
B05D 1/20 (2006.01), G01N 27/00 (2006.01), G01N 33/543 (2006.01)
Applicants: TECHNOBIOCHIP [IT/IT]; Via Roma, 28, I-57030 Marciana (IT) (For All Designated States Except US).
SARTORE, Marco [IT/IT]; (IT) (For US Only).
ADAMI, Manuela [IT/IT]; (IT) (For US Only).
NICOLINI, Claudio [IT/IT]; (IT) (For US Only).
TROITSKY, Vladimir [RU/RU]; (RU) (For US Only)
Inventors: SARTORE, Marco; (IT).
ADAMI, Manuela; (IT).
NICOLINI, Claudio; (IT).
TROITSKY, Vladimir; (RU)
Priority Data:
9414190.0 14.07.1994 GB
9418069.2 08.09.1994 GB
Title (EN) BIOSENSOR AND METHOD AND INSTRUMENT FOR DEPOSITION OF ALTERNATING MONOMOLECULAR LAYERS
(FR) BIOCAPTEUR, ET PROCEDE ET INSTRUMENT PERMETTANT DE DEPOSER DES COUCHES MONOMOLECULAIRES ALTERNEES
Abstract: front page image
(EN)A gravimetric biosensor based on two quartz resonators with immobilised layers of antibodies was developed. The active oscillator is covered by antibodies specific to a given antigen, while the reference oscillator is covered by antibodies non-specific to the antigen, in order to compensate the physical absorption effects. In a second aspect the invention provides a method and instrument for depositing films of alternating monomolecular layers, which can contain monolayers of surfactant molecules and monolayers of soluble adsorbed compounds. The first and second aspect in combination can provide a biosensor having alternating monomolecualr layers with at least one layer being biosensitive, e.g. immunosensitive.
(FR)Un biocapteur gravimétrique doté de deux résonateurs à quartz présente des couches d'anticorps immobilisées. L'oscillateur actif est recouvert d'anticorps spécifiques d'un antigène donné, tandis que l'oscillateur de référence est recouvert d'anticorps non spécifiques de l'antigène pour compenser les effets physiques d'absorption. Dans un deuxième aspect, l'invention concerne un procédé et un instrument permettant de déposer des revêtements composés de couches monomoléculaires alternées qui peuvent comporter des monocouches de molécules de surfactants et des monocouches de composés adsorbés solubles. Combinés, les deux aspects de l'invention procurent un biocapteur à couches monomoléculaires alternées dont l'une au moins est biosensible, c'est-à-dire immunosensible.
Designated States: AM, AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LT, LU, LV, MD, MG, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TT, UA, UG, US, UZ, VN.
African Regional Intellectual Property Organization (KE, MW, SD, SZ, UG)
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)