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1. WO1996002824 - HIGH-SPEED FLUORESCENCE SCANNER

Publication Number WO/1996/002824
Publication Date 01.02.1996
International Application No. PCT/US1995/007834
International Filing Date 20.06.1995
IPC
G01N 21/64 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
G01N 27/447 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
416Systems
447using electrophoresis
CPC
G01N 2021/6417
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
6417Spectrofluorimetric devices
G01N 21/6452
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
645Specially adapted constructive features of fluorimeters
6452Individual samples arranged in a regular 2D-array, e.g. multiwell plates
G01N 2201/101
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
2201Features of devices classified in G01N21/00
10Scanning
101Scanning measuring head
G01N 27/44721
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
26by investigating electrochemical variables; by using electrolysis or electrophoresis
416Systems
447using electrophoresis
44704Details; Accessories
44717Arrangements for investigating the separated zones, e.g. localising zones
44721by optical means
Applicants
  • MOLECULAR DYNAMICS [US/US]; 928 East Arques Avenue Sunnyvale, CA 94086, US
Inventors
  • HUETON, Iain; US
  • VAN GELDER, Ezra; US
Agents
  • SCHNECK, Thomas; Schneck & McHugh P.O. Box 2-E San Jose, CA 95109-0005, US
Priority Data
277,90019.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HIGH-SPEED FLUORESCENCE SCANNER
(FR) DISPOSITIF D'EXPLORATION A FLUORESCENCE EXTREMEMENT RAPIDE
Abstract
(EN)
A high-speed fluorescence scanner for scanning a sample at equal angles has most of its optical components, including a light beam source (11), a detector (19), filters (18), lenses (17), and reflectors (15-16), in a fixed position (24), removed from the scan head (22). The lightweight scan head contains a single reflector (13) and lens (12) combination which is reciprocated rapidly along one axis to lengthen and shorten a region of the path of a collimated excitation beam (30) and to form a scan line (25-26) on a sample. The fluorescence emission is gathered by the lens (12) of the scan head and directed back, generally along the optical path of the excitation beam, to a detector. Another embodiment places the light source (43), in miniature form, directly on the scan head. The sample may be translated in an axis orthogonal to the scan line to stimulate fluorescent emission from two-dimensional portion of the sample.
(FR)
Dispositif d'exploration à fluorescence extrêmement rapide servant à explorer un échantillon à des angles égaux et dont la plupart des composants optiques, c'est-à-dire une source de faisceau lumineux (11), un détecteur (19), des filtres (18), des lentilles (17) et des réflecteurs (15-16) ont une position fixe (24) éloignée de la tête d'exploration (22). La tête d'exploration légère contient une combinaison constituée par un réflecteur unique (13) et par une lentille (12) qui effectue un déplacement alternatif rapide le long d'un axe, de manière à rallonger et à raccourcir une région du trajet d'un faisceau d'excitation collimaté (30), ainsi qu'à créer une ligne de balayage (25-26) sur un échantillon. L'émission fluorescente est recueillie par la lentille (12) de la tête de lecture et renvoyée à un détecteur, généralement le long du trajet optique du faisceau d'excitation. Dans un autre mode de réalisation, la source lumineuse miniaturisée (43) est placée directement sur la tête d'exploration. L'échantillon peut être soumis à une translation dans un axe orthogonal à la ligne de balayage, afin de stimuler l'émission fluorescente depuis une partie bidimensionnelle dudit échantillon.
Also published as
Latest bibliographic data on file with the International Bureau