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1. WO1996002671 - SEQUENCE-BASED MUTATION ANALYSIS OF NEOPLASTIC TISSUE FOR DIAGNOSIS OR PROGNOSIS OF THE NEOPLASIA

Publication Number WO/1996/002671
Publication Date 01.02.1996
International Application No. PCT/SE1995/000804
International Filing Date 29.06.1995
Chapter 2 Demand Filed 02.02.1996
IPC
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/106
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
Applicants
  • PHARMACIA BIOTECH AB [SE/SE]; S-751 82 Uppsala, SE (AllExceptUS)
  • BYWATER, Margaret [GB/SE]; SE (UsOnly)
  • LINDSTRÖM, Per [SE/SE]; SE (UsOnly)
  • INGANÄS, Mats [SE/SE]; SE (UsOnly)
Inventors
  • BYWATER, Margaret; SE
  • LINDSTRÖM, Per; SE
  • INGANÄS, Mats; SE
Agents
  • EBBINGHAUS, Marie-Louise ; Pharmacia AB Patent Dept. S-751 82 Uppsala, SE
Priority Data
9402487-415.07.1994SE
9403953-416.11.1994SE
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) SEQUENCE-BASED MUTATION ANALYSIS OF NEOPLASTIC TISSUE FOR DIAGNOSIS OR PROGNOSIS OF THE NEOPLASIA
(FR) ANALYSE PAR SEQUENÇAGE DES MUTATIONS DE TISSUS NEOPLASIQUES POUR LE DIAGNOSTIC OU LE PRONOSTIC DES NEOPLASIES
Abstract
(EN)
A method for sequence-based diagnosis of a human neoplastic tissue, blood or other body fluid sample, comprises analysing from genomic DNA or cDNA derived from said neoplasia the DNA sequence of a gene encoding a cancer-related protein for the presence of mutations therein, determining from the presence, nature and location of any such mutation or mutations the influence thereof on the biological function of the corresponding protein and thereby on the properties of the neoplasia, and on the basis thereof prognosticating the development of the neoplasia.
(FR)
La présente invention concerne un procédé de diagnostic par séquençage d'un échantillon de tissu néoplasique, de sang ou d'autre fluide biologique d'origine humaine. Le procédé consiste à analyser à partir de l'ADN génomique ou de l'ADNc dérivé de la néoplasie considérée, la séquence d'ADN d'un gène codant une protéine liée au cancer, afin d'y détecter la présence de mutations, et de déterminer, d'après la présence, la nature et l'emplacement d'une telle mutation ou de telles mutations, leur influence sur la fonction biologique de la protéine correspondante, et par conséquent sur les propriétés de la néoplasie. Le procédé consiste ensuite, à partir de ces résultats, à établir un pronostic concernant le développement de la néoplasie.
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