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1. WO1996002670 - METHODS OF PROGNOSING THE COURSE AND DEGREE OF DEMENTIA IN PATIENTS WITH BETA-AMYLOID-RELATED DISEASES

Publication Number WO/1996/002670
Publication Date 01.02.1996
International Application No. PCT/EP1995/002823
International Filing Date 12.07.1995
Chapter 2 Demand Filed 26.01.1996
IPC
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/775 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
775Apolipopeptides
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/775
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
775Apolipopeptides
C12Q 1/6883
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
C12Q 2600/112
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
112Disease subtyping, staging or classification
C12Q 2600/118
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
118Prognosis of disease development
C12Q 2600/156
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
Applicants
  • SMITHKLINE BEECHAM PLC [GB/GB]; New Horizons Court Brentford Middlesex TW8 9EP, GB (AllExceptUS)
  • UNIVERSITY OF SOUTH FLORIDA [US/US]; 4202 East Fowler Avenue FAO 126 Tampa, FL 33620, US (AllExceptUS)
  • ROYSTON, Maureen, Claire [GB/GB]; GB
  • ROBERTS, Gareth, Wyn [GB/GB]; GB (UsOnly)
  • HARDY, John [GB/US]; US (UsOnly)
Inventors
  • ROYSTON, Maureen, Claire; GB
  • ROBERTS, Gareth, Wyn; GB
  • HARDY, John; US
Agents
  • GIDDINGS, Peter, John; SmithKline Beecham Corporate Intellectual Property SB House, Great West Road Brentford Middlesex TW8 9BD, GB
Priority Data
9414624.820.07.1994GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF PROGNOSING THE COURSE AND DEGREE OF DEMENTIA IN PATIENTS WITH BETA-AMYLOID-RELATED DISEASES
(FR) PROCEDE POUR PRONOSTIQUER L'EVOLUTION ET LE DEGRE DE LA DEMENCE CHEZ DES PATIENTS ATTEINTS DE $g(b)-AMYLOSES
Abstract
(EN)
A method of prognosing in a subject for the course and nature of disease progression and the ultimate degree of dementia which a subject would suffer during a $g(b) amyloid-related disease, wherein the presence of an ApoE2 isoform or DNA in a subject at risk of such disease or suspected of having such a disease or in the early stages of such a disease indicates that the subject is likely to have a milder, more benign course of disease with the extent of the eventual cognitive impairment or dementia being of mild or moderate degree, the method comprising detecting the presence or absence of ApoE isoforms or of DNA encoding ApoE isoforms in the subject.
(FR)
L'invention concerne un procédé pour pronostiquer chez un sujet l'évolution et la nature de la progression de la maladie et le degré ultime de démence dont il souffrirait lors d'une $g(b)-amylose. La présence d'une isoforme d'ApoE2 ou d'ADN chez un sujet exposé à cette maladie ou soupçonné d'avoir contracté cette maladie ou se trouvant au stade précoce de cette maladie, indique que ce sujet est susceptible de présenter une évolution plus bégnine de la maladie, l'ampleur de la déficience cognitive ou de la démence éventuelles étant peu importante ou modérée. Ce procédé consiste à détecter chez le sujet la présence ou l'absence d'isoformes d'ApoE ou d'ADN codant pour des isoformes d'ApoE.
Also published as
Latest bibliographic data on file with the International Bureau