Processing

Please wait...

Settings

Settings

1. WO1996002642 - INTERRUPTION OF BINDING OF MDM2 AND p53 PROTEIN AND THERAPEUTIC APPLICATION THEREOF

Publication Number WO/1996/002642
Publication Date 01.02.1996
International Application No. PCT/GB1995/001719
International Filing Date 20.07.1995
Chapter 2 Demand Filed 23.01.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/82 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
82Translation products from oncogenes
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 14/4746
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4746p53
C07K 14/82
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
82Translation products from oncogenes
Y10S 436/813
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
436Chemistry: analytical and immunological testing
811Test for named disease, body condition or organ function
813Cancer
Applicants
  • UNIVERSITY OF DUNDEE [GB/GB]; Dundee DD1 4HN, GB (AllExceptUS)
  • PICKSLEY, Steven, Michael [GB/GB]; GB (UsOnly)
  • LANE, David, Philip [GB/GB]; GB (UsOnly)
Inventors
  • PICKSLEY, Steven, Michael; GB
  • LANE, David, Philip; GB
Agents
  • GREAVES, Carol, P. ; Mewburn Ellis York House 23 Kingsway London WC2B 6HP, GB
Priority Data
08/277,66020.07.1994US
08/424,95719.04.1995US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INTERRUPTION OF BINDING OF MDM2 AND p53 PROTEIN AND THERAPEUTIC APPLICATION THEREOF
(FR) INTERRUPTION DE LA LIAISON DE LA PROTEINE MDM2 ET p53 ET SON APPLICATION THERAPEUTIQUE
Abstract
(EN)
Compounds for use in interfering with the binding between p53 and MDM2 or a protein having a p53 binding site analogous to that of MDM2, the compound being selected from the group consisting of a peptide having up to twenty-eight amino acids which is able to disrupt or prevent binding between p53 and MDM2, or a functional peptide analogue thereof. Methods for detecting such compounds and their application in the diagnosis and treatment of tumours is also described and claimed.
(FR)
Des composés sont utilisés pour interférer avec la liaison entre la protéine p53 et MDM2 ou une protéine possédant un site de liaison sur la p53 analogue à celui de la MDM2, le composé étant sélectionné dans le groupe constitué d'un peptide possédant jusqu'à 28 acides aminés qui peut interrompre ou empêcher la liaison entre p53 et MDM2, ou un analogue peptidique fonctionnel de ces protéines. Des procédés de détection de ces composés et leur application dans le diagnostic et le traitement de tumeurs sont également décrits et revendiqués.
Also published as
NZ289899
Latest bibliographic data on file with the International Bureau