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1. WO1996002641 - MATERIALS AND METHODS RELATING TO THE DIAGNOSIS AND PROPHYLACTIC AND THERAPEUTIC TREATMENT OF SYNOVIAL SARCOMA

Publication Number WO/1996/002641
Publication Date 01.02.1996
International Application No. PCT/GB1995/001704
International Filing Date 19.07.1995
Chapter 2 Demand Filed 31.01.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12Q 1/68 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/156
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
156Polymorphic or mutational markers
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
Applicants
  • CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED [GB/GB]; Cambridge House 6-10 Cambridge Terrace Regent's Park London NW1 4JL, GB (AllExceptUS)
  • COOPER, Colin, Stephen [GB/GB]; GB (UsOnly)
  • GUSTERSON, Barry, Austin [GB/GB]; GB (UsOnly)
Inventors
  • COOPER, Colin, Stephen; GB
  • GUSTERSON, Barry, Austin; GB
Agents
  • MEWBURN ELLIS; York House 23 Kingsway London WC2B 6HP, GB
Priority Data
9414580.219.07.1994GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) MATERIALS AND METHODS RELATING TO THE DIAGNOSIS AND PROPHYLACTIC AND THERAPEUTIC TREATMENT OF SYNOVIAL SARCOMA
(FR) PRODUITS ET PROCEDES RELATIFS AU DIAGNOSTIC ET AU TRAITEMENT PROPHYLACTIQUE ET THERAPEUTIQUE DU SYNOVIOSARCOME
Abstract
(EN)
The invention provides a method for diagnosing the presence or absence of synovial sarcoma which comprises obtaining a sample derived from a tissue of a subject; contacting the sample with a specific binding member (sbm) which is specific for a binding partner (bp) which is characteristic of synovial sarcoma such that the presence of bp in the sample is diagnostic of synovial sarcoma, the bp being absent from an equivalent sample derived from a subject without synovial sarcoma; and detecting any binding of the sbm to its bp. Binding partners characteristic of synovial sarcoma are SSX and SYT sequences and fusion sequences thereof. Sequences, reagents and therapeutic methods and pharmaceuticals are also provided.
(FR)
L'invention se rapporte à un procédé visant à diagnostiquer la présence ou l'absence de synoviosarcome et consistant à obtenir un échantillon prélevé dans un tissu d'un patient; mettre l'échantillon en contact avec un élément de liaison spécifique (sbm) qui est spécifique d'un partenaire de liaison (bp), ce dernier étant caractéristique du synoviosarcome, de sorte que la présence de bp dans l'échantillon révèle la présence du synoviosarcome, bp étant absent d'un échantillon équivalent prélevé chez un patient ne souffrant pas de synoviosarcome; et détecter toute liaison de sbm avec son bp. Les caractéristiques des partenaires de liaison du synoviosarcome sont les séquences SSX et SYT et les séquences de fusion de celles-ci. L'invention se rapporte également à des séquences, des réactifs et des procédés thérapeutiques ainsi qu'à des produits pharmaceutiques.
Also published as
NZ289893
Latest bibliographic data on file with the International Bureau