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1. WO1996002640 - ALPHA-LACTALBUMIN GENE CONSTRUCTS

Publication Number WO/1996/002640
Publication Date 01.02.1996
International Application No. PCT/GB1995/001651
International Filing Date 12.07.1995
Chapter 2 Demand Filed 30.01.1996
IPC
A23C 9/20 2006.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
CDAIRY PRODUCTS, e.g. MILK, BUTTER, CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
9Milk preparations; Milk powder or milk powder preparations
20Dietetic milk products not covered by groups A23C9/12-A23C9/1897
C07K 14/76 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
76Albumins
C12N 15/85 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
CPC
A01K 2207/15
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2207Modified animals
15Humanized animals
A01K 2217/00
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
A01K 2217/05
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
05Animals comprising random inserted nucleic acids (transgenic)
A01K 2217/075
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2217Genetically modified animals
07Animals genetically altered by homologous recombination
075inducing loss of function, i.e. knock out
A01K 2227/101
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
101Bovine
A01K 2227/105
AHUMAN NECESSITIES
01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
2227Animals characterised by species
10Mammal
105Murine
Applicants
  • PPL THERAPEUTICS (SCOTLAND) LTD. [GB/GB]; Roslin Edinburgh EH25 9PP, GB (AllExceptUS)
  • COOPER, Julian [GB/US]; US (UsOnly)
  • SCHNIEKE, Angelike [DE/GB]; GB (UsOnly)
Inventors
  • COOPER, Julian; US
  • SCHNIEKE, Angelike; GB
Agents
  • MURGITROYD & COMPANY; 373 Scotland Street Glasgow G5 8QA, GB
Priority Data
08/381,69131.01.1995US
9425326.715.12.1994GB
9503822.025.02.1995GB
PCT/GB94/0151413.07.1994AT
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ALPHA-LACTALBUMIN GENE CONSTRUCTS
(FR) STRUCTURES GENIQUES D'ALPHA-LACTALBUMINE
Abstract
(EN)
The present invention provides recombinant gene constructs for expressing the protein $g(a)-lactalbumin, especially human $g(a)-lactalbumin, in bovine cells. Novel genetic constructs, vectors and transformed cells are provided as well as transgenic animals genetically engineered for enhanced expression of $g(a)-lactalbumin. Human $g(a)-lactalbumin has been shown to be superior for human infant nutrition and the present invention enables a cheap and effective form for production of the major whey protein in human milk.
(FR)
Structures géniques recombinées destinées à exprimer dans des cellules bovines la protéine $g(a)-lactalbumine, notamment l'$g(a)-lactalbumine humaine. On décrit des nouvelles structures géniques, des vecteurs et des cellules modifiées, de même que des animaux transgéniques obtenus par génie génétique, aux fins d'une expression accrue de l'$g(a)-lactalbumine. L'$g(a)-lactalbumine humaine s'est révélée être supérieure pour la nutrition de l'enfant, et la présente invention permet d'obtenir une forme de production bon marché et efficace, dans le lait humain, de la protéine principale du petit lait.
Also published as
KR1019970700197
NZ289197
Latest bibliographic data on file with the International Bureau