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1. WO1996002576 - RECONSTITUTED HUMAN ANTIBODY AGAINST HUMAN INTERLEUKIN-8

Publication Number WO/1996/002576
Publication Date 01.02.1996
International Application No. PCT/JP1995/001396
International Filing Date 12.07.1995
Chapter 2 Demand Filed 01.09.1995
IPC
C07K 16/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
CPC
A61K 2039/505
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
505comprising antibodies
C07K 16/244
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
24against cytokines, lymphokines or interferons
244Interleukins [IL]
C07K 2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2319/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
Applicants
  • CHUGAI SEIYAKU KABUSHIKI KAISHA [JP/JP]; 5-1, Ukima 1-chome Kita-ku Tokyo 115, JP (AllExceptUS)
  • MATSUSHIMA, Kouji [JP/JP]; JP (UsOnly)
  • MATSUMOTO, Yoshihiro [JP/JP]; JP (UsOnly)
  • YAMADA, Yoshiki [JP/JP]; JP (UsOnly)
  • SATO, Koh [JP/JP]; JP (UsOnly)
  • TSUCHIYA, Masayuki [JP/JP]; JP (UsOnly)
  • YAMAZAKI, Tatsumi [JP/JP]; JP (UsOnly)
Inventors
  • MATSUSHIMA, Kouji; JP
  • MATSUMOTO, Yoshihiro; JP
  • YAMADA, Yoshiki; JP
  • SATO, Koh; JP
  • TSUCHIYA, Masayuki; JP
  • YAMAZAKI, Tatsumi; JP
Agents
  • ISHIDA, Takashi ; A. Aoki & Associates Toranomon 37 Mori Building 5-1, Toranomon 3-chome Minato-ku Tokyo 105, JP
Priority Data
6/16148113.07.1994JP
6/28995124.11.1994JP
6/31078514.12.1994JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) RECONSTITUTED HUMAN ANTIBODY AGAINST HUMAN INTERLEUKIN-8
(FR) ANTICORPS HUMAIN RECONSTITUE CONTRE L'INTERLEUKINE-8 HUMAINE
Abstract
(EN)
A reconstituted human antibody against human interleukin-8 (IL-8), comprising (A) L chains comprising: (1) the human L-chain C region, and (2) the L-chain V region containing the human L-chain FR and the L-chain CDR of a mouse monoclonal antibody against IL-8; and (B) H chains comprising: (1) the human H-chain C region, and (2) the H-chain V region containing the human H-chain FR and the H-chain CDR of a mouse monoclonal antibody against IL-8. As the major part of the reconstituted antibody derives from a human antibody and antigenicity of the CDR is low, this antibody has a low antigenicity against the human body, thus being expected to be applicable for medical therapy.
(FR)
Anticorps humain reconstitué dirigé contre l'interleukine-8 (IL-8) humaine comprenant (A) des chaînes L comportant: (1) la région C de la chaîne L humaine, (2) la région V de la chaîne L contenant la chaîne L humaine FR, et la chaîne L CDR d'un anticorps monoclonal de souris dirigé contre l'IL-8; et (B) des chaînes H comportant: (1) la région C de la chaîne H humaine, (2) la région V de la chaîne H humaine contenant la chaîne H FR, et la chaîne H CDR d'un anticorps monoclonal de souris dirigé contre l'IL-8. Comme la majeure partie de l'anticorps reconstitué dérive d'un anticorps humain, le caractère antigénique de CRD est faible, notamment vis-à-vis du corps humain, ce qui permet de l'envisager pour des traitmeents médicaux.
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